Project Grant R01ES038190
- The National Institute of Environmental Health Sciences awarded the University of Southern California $4.061 million on August 25, 2026, under the Environmental Health program (CFDA 93.113, Assistance Listing R01ES038742) to investigate phthalate exposure, dietary effect modification, and human reproductive health. The research addresses whether serum levels of n-3 polyunsaturated fatty acids and carotenoids modify the adverse reproductive effects of phthalate exposure. The project will evaluate...
- The National Institute of Environmental Health Sciences awarded Clemson University $167,562 under the Environmental Health program (CFDA 93.113) on August 20, 2026, to investigate the effects of preconception phthalate exposure on implantation and placentation. The project addresses a knowledge gap in reproductive toxicology by examining how endocrine-disrupting chemical exposure during the preconception window—between puberty and pregnancy—affects maternal reproductive tissue adaptations that...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded $2.74 million under the Environmental Health program (CFDA 93.113) to the University of Illinois to investigate the neurodevelopmental impacts of phthalate exposure on social behavior circuits. The project, which commenced September 15, 2025, and will conclude September 14, 2029, will deliver comprehensive research examining how developmental exposure to phthalates—ubiquitous industrial...
- Federal Grant Award Summary Midwestern University received a $521,992 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective September 1, 2025, through August 31, 2028. The grant supports research and career development activities investigating how phthalate exposure disrupts reproductive function through Liver Receptor Homolog-1 (LRH1) signaling pathways in Sertoli cells. The primary deliverables include...
- The National Institute of Environmental Health Sciences awarded the University of North Carolina at Chapel Hill $495,067 on September 12, 2025, under the Environmental Health program (CFDA 93.113) to investigate associations between prenatal phthalate and phthalate alternative exposures and fetal and pediatric cardiometabolic outcomes. The research uses the HPP-3D study cohort, which documented phthalate exposure in 90% of pregnancies. The award funds two phases of work. During the K99 phase,...
- The National Institute of Environmental Health Sciences awarded the University of Maryland, College Park $426,346 on May 10, 2026, under the Environmental Health program (CFDA 93.113) to investigate the direct effects of endocrine disrupting chemicals on the vaginal microenvironment. The award funds research examining how phthalates and other endocrine-disrupting chemicals interfere with estrogen signaling and promote vaginal dysbiosis—a polymicrobial microbiome condition present in...
- The National Institute of Environmental Health Sciences awarded Drexel University $111,199 on April 3, 2026, under the Environmental Health program (CFDA 93.113) to investigate the role of phthalates, phenols, and their sources on phenotypic variability in autism and co-occurring neurodevelopmental disorders, obesity, and asthma. The recipient will use data from the Environmental Influences on Child Health Outcomes (ECHO) program, an NIH-funded consortium of longitudinal U.S.-based cohort...
- Federal Project Grant Award Summary Brown University received a $463,850 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded on September 10, 2025, with a completion date of September 9, 2027. The award supports research investigating associations between prenatal per- and polyfluoroalkyl substances (PFAS) mixture exposure and long-term health outcomes in adulthood. The research leverages the New England...
- Federal Project Grant Award Summary Texas A&M University System Health Science Center received a $2.47 million Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded September 15, 2025, with completion anticipated by September 14, 2029. The award supports mechanistic research investigating phthalate-induced epigenetic regulations in adipose tissues and their role in metabolic dysfunction. The project...
- The National Institute of Environmental Health Sciences awarded the University of Massachusetts $752,690 on August 13, 2026, for research on preconception and early pregnancy exposure to endocrine-disrupting chemicals under the Environmental Health grant program (CFDA 93.113). The project investigates how exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS), polybrominated diphenyl ethers (PBDEs), and trace elements affects women's reproductive health and the ability to achieve...
The National Institute of Environmental Health Sciences awarded Brown University $582,295 on August 21, 2026, under the Environmental Health program (CFDA 93.113) to investigate mechanisms of phthalate toxicity in testicular development and long-term reproductive function. The project, titled "Mechanisms of Phthalate Toxicity in Testis Development and Later-Life Function," will define how phthalate exposure during fetal development disrupts testicular germ cell development and seminiferous cord formation, characterize persistent effects on sperm RNA and adult male fertility, and examine whether paternal early-life or preconception phthalate exposure causes adverse effects on offspring development through biological signaling in sperm. Phthalates are plasticizers and additives in consumer products including personal care items; humans face broad low-level exposure, with medical interventions such as blood transfusions creating pathways to higher exposure. The research models testicular dysgenesis syndrome, a pattern of declining male reproductive health marked by reduced sperm count and increased infertility. The award supports research conducted at Brown University in Providence, Rhode Island, with a period of performance extending from August 21, 2026, through June 30, 2031. The assistance type is a project grant, awarded on the basis of peer review by study section for scientific merit and secondary review by the National Institute's Advisory Council.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $582.3k | 8/20/26 |