Project Grant R01ES037626
- Grant Award Summary New York University School of Medicine received a $2,518,755 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective September 16, 2025 through September 15, 2029. The research focuses on elucidating the mechanisms of chromium(VI) [Cr(VI)] carcinogenesis, specifically investigating how the NEDD9 (Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 9) scaffolding...
- Federal Project Grant Award Summary New York University School of Medicine received a $1,124,358 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded on August 22, 2025, with a completion date of May 31, 2030. This research grant funds a comprehensive investigation into the effects of hexavalent chromium [CR(VI)] exposure on skeletal muscle differentiation and regeneration. The project builds on...
- Federal Grant Award Summary New York University School of Medicine received a $10.9 million Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective September 15, 2025, through September 14, 2029. This translational research initiative investigates the accumulation of micro- and nanoplastic particles (MNPs) in mammalian tissues to address a significant and understudied public health exposure...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded The University of Texas Southwestern Medical Center a Project Grant of $649,193 effective April 1, 2026 through March 31, 2031 under the Environmental Health program (CFDA 93.113). This research grant supports investigations into the molecular mechanisms by which heavy metals—including arsenic, cadmium, chromium, and nickel—dysregulate epitranscriptomic processes and induce pathogenesis....
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded the University of Rochester a $716,066 Project Grant on September 19, 2025, under the Environmental Health program (CFDA 93.113) to investigate the mechanisms of environmentally-induced bronchiolitis obliterans (BO). This devastating lung disease of the small airways is increasingly associated with occupational inhalation exposures to reactive diketone chemicals, particularly...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded New York University School of Medicine a Project Grant totaling $497,998 under the Environmental Health program (CFDA 93.113) beginning June 2, 2026, with completion scheduled for May 31, 2029. This research initiative, titled "Epigenetic and Genetic Regulation of Arsenic Methylation and Arsenic-Related Cardiovascular Disease Risk," will deliver mechanistic and epidemiological...
- Federal Grant Award Summary NYU Grossman School of Medicine, in collaboration with Erasmus University Medical Center, received $1,694,996 in funding from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) for a Project Grant awarded August 1, 2025, with completion expected by May 31, 2030. The award supports a life-course epidemiological study investigating how environmental chemical exposures—specifically organophosphate...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded a $814,154 Project Grant (CFDA 93.113, Environmental Health program) to The Research Foundation For The State University Of New York on April 1, 2026, with completion scheduled for March 31, 2031. The project, titled "Epitranscriptomic and Epigenetic Loops Driving the Response to Naphthalene," investigates the interplay between epitranscriptomic modifications (RNA-based...
- Federal Project Grant Award Summary Weill Medical College of Cornell University received a $100,228 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded October 4, 2026, with completion targeted for May 31, 2029. This research project investigates the functional mechanisms of the SMC5/6 protein complex, specifically examining how two competing conformational states (NSE4-neck and NSE6-neck) regulate the...
- Federal Project Grant Award Summary Award: New York University School of Medicine received a $4.128 million Project Grant from the National Institute of Environmental Health Sciences (NIEHS) Environmental Health program (CFDA 93.113), awarded April 22, 2026, with completion targeted for April 21, 2030. The research delivers a quasi-experimental evaluation of the health impacts of New York City's congestion pricing policy, the first cordon-based congestion charge implemented in the United States....
New York University School of Medicine received a $3.23M Project Grant from the National Institute of Environmental Health Sciences (NIEHS) Environmental Health program (CFDA 93.113) awarded on June 20, 2026, with a completion date of June 19, 2030. The grant funds research into the molecular mechanisms underlying nickel (Ni) exposure-associated lung diseases. The project investigates how occupational and environmental nickel exposure disrupts SP1/ZEB1-dependent transcriptional regulation, with a focus on gene silencing mechanisms that persist after exposure cessation. Preliminary findings indicate that nickel exposure causes sustained downregulation of genes involved in cell adhesion and extracellular matrix organization, including E-cadherin (CDH1), which triggers epithelial-mesenchymal transition (EMT) and tumor suppressor gene silencing—key pathogenic processes linked to chronic inflammatory lung diseases such as asthma, fibrosis, bronchitis, emphysema, and chronic obstructive pulmonary disease (COPD). The research deliverables include mechanistic studies characterizing how nickel induces transcription factor displacement from gene promoters and sustained epigenetic modifications, with the ultimate goal of uncovering molecular targets for therapeutic intervention in nickel-associated lung and nasal cancers. This project addresses a significant occupational and environmental health threat given the widespread industrial use of nickel-containing products and documented associations between nickel exposure and decreased pulmonary function in both children and adults.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 6/23/26 |