Project Grant R01ES036591
- The Project Grant award of $2,518,755 from the National Institute of Environmental Health Sciences (CFDA 93.113 Environmental Health) supports research conducted by New York University School of Medicine to investigate the mechanisms by which the carcinogen chromium(VI) and the scaffolding protein NEDD9 contribute to the development of non-small cell lung cancer. The research aims to elucidate how chronic chromium(VI) exposure impairs autophagy, leading to the upregulation of the protein p62 and...
- This $646,476 federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to understand how environmental chemicals, specifically inorganic arsenic, impact the epigenome and cause heritable effects. The University of California, Los Angeles (UCLA) is the primary awardee and will leverage a unique mouse embryonic stem cell model to investigate how arsenic exposure leads to epigenetic...
- This Project Grant award of $5,453,538.00 was provided by the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program. The award will support research by New York University School of Medicine to investigate the accumulation of micro- and nanoplastic particles in mammalian tissues, including quantifying their concentrations across different tissue types, age groups, and demographics. The research aims to improve...
- The National Institute of Environmental Health Sciences (NIEHS) awarded a $847,498 Project Grant under the Environmental Health (CFDA 93.113) program to the NYU Grossman School of Medicine and Erasmus University Medical Center. The grant funding supports a collaborative research project to evaluate how exposures to organophosphate pesticides, glyphosate, phthalates, and bisphenols during fetal development and childhood impact the risk of chronic kidney disease in children and adolescents. The...
- This $456,500 Project Grant was awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program. The grant aims to identify and characterize the Drosophila (fruit fly) NSE5/6 protein complex, which is a key regulator of the SMC5/6 complex that plays a critical role in the repair of DNA double-strand breaks in heterochromatin regions of the genome. The research will elucidate the mechanisms by which NSE5/6 coordinates...
- This $719,892 federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, will support research on the relationship between infant exposure to phthalates and bisphenols, and reproductive development during the "minipuberty" period of the first six months of life. The research, to be conducted by New York University (NYU), will examine both in-utero and concurrent chemical exposures in 480...
- This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program provides $379,504 to the University System of New Hampshire's Keene State College to conduct research on the tissue-specific development of toxicity in response to transgenerational chronic arsenic exposures. The key objectives are to: (1) detect tissue-specific uptake of arsenic in response to transgenerational chronic exposure; (2)...
- This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $127,384 to the University of Pittsburgh to conduct research on the dynamics of oxidative DNA demethylation from duplex DNA to chromatin. The research aims to investigate how the presence of chromatin impacts the efficiency of active DNA demethylation, a key process in gene expression regulation. Specifically, the project will study the...
- This federal Project Grant award of $113,168.00 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to investigate how the protein XRCC1 facilitates the enzyme DNA polymerase beta (Pol β) in repairing oxidative DNA damage within chromatin. The primary objectives are to: 1) Determine how Pol β and XRCC1 search for and recognize DNA damage within chromatin, and 2) Establish the structural and mechanistic...
- This federal Project Grant award of $464,133 from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, supports research to study the proteome of dopaminergic neurons in an in vivo model of manganese neurotoxicity. The research aims to identify the molecular signatures and potential drug targets associated with manganese-induced neurodegeneration, which is linked to Parkinson's disease. The award recipient is the University of...
This $503,642 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research by New York University (NYU) investigating the impact of exposure to hexavalent chromium (Cr(VI)) on skeletal muscle development and regeneration. The research aims to determine whether Cr(VI) exposure, which is associated with various health effects, adversely affects skeletal muscle differentiation and regeneration in vivo. The project builds on NYU's prior in vitro and ex vivo findings demonstrating that Cr(VI) inhibits myogenic differentiation. The 5-year project will utilize animal models to assess the effects of Cr(VI) exposure on skeletal muscle development and regeneration processes. The research seeks to advance the understanding of how environmental Cr(VI) exposures impact the largest organ in the human body.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $503.6k | 8/20/25 |