This Project Grant award, provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program, supports research on the role of albumin and other serum factors in the accumulation and toxicity of per- and polyfluoroalkyl substances (PFAS) in the body. The $385,219 award, with a project period from May 2025 to February 2030, aims to determine whether albumin is a key factor for PFAS distribution, elimination, and associated liver effects. The research will be conducted by the University of Rhode Island, a sub-recipient under the State of Rhode Island. Key objectives include: 1) quantifying PFAS tissue accumulation and binding in mice with and without albumin, 2) investigating albumin's role as a mediator of PFAS-induced liver toxicity, and 3) evaluating the impact of genetic and disease-related variations in albumin and globulin levels on PFAS exposure and liver disease susceptibility in humans using a toxicokinetic model. The findings from this research are expected to define the relevance of albumin for PFAS bioaccumulation and hepatotoxicity compared to other macromolecules.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $385.2k | 5/13/25 |