This three-year $893,704 project grant from the National Institutes of Health's National Institute of Environmental Health Sciences will fund research at DePaul University to study the direct effects of polychlorinated biphenyls (PCBs) on microglial function across sexes and developmental stages. The central hypothesis is that PCB exposure will prime microglia—the resident immune cells of the brain—to produce exaggerated responses to secondary challenges in an age- and sex-specific...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program aims to investigate the neurotoxic and neurodevelopmental health risks of per- and polyfluoroalkyl substances (PFAS). The $546,350 award, which begins on January 13, 2025 and runs through October 31, 2029, will fund research to: (1) define the chemical interactions that mediate neuronal uptake and accumulation of PFAS, (2) elucidate the neurotoxic...
This $428,387 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to synthesize environmentally relevant micro- and nanoplastics and evaluate their toxicological effects. The primary awardee, Purdue University, is developing a novel procedure to generate plastic particles representative of environmental exposures, and will investigate how the physicochemical properties of these...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, provides $1,968,864 to Purdue University to conduct research evaluating and comparing the neurotoxic effects of exposure to various per- and polyfluoroalkyl substances (PFAS), including legacy PFOA and replacement chemicals PFBA and GenX. The research aims to characterize the impact of low-dose developmental PFAS exposure on...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, aims to investigate the impact of developmental polychlorinated biphenyls (PCBs) exposure on bladder contractility and the development of lower urinary tract symptoms (LUTS). The $372,100 award, effective September 1, 2024 through June 30, 2029, will allow researchers at the University of Wisconsin - Madison to test the hypothesis...
This $418,702 federal Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) will support research at Baylor University to investigate the impact of altered biotransformation pathways on the ability of Gulf killifish to adapt to legacy pollutants like polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs). The project will examine how a deletion in the aryl hydrocarbon receptor (AhR)...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program will fund research to investigate the relationship between exposure to the antimicrobial and endocrine disrupting compound triclosan, pubertal hormones, the adolescent gut microbiome, and neurobehavioral development. The total funding amount is $776,150.33 with a project period from September 1, 2024 to August 31, 2027.
The key objectives...
This $107,493 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program will support research at the University of Michigan to characterize the risk and protective effects of environmental co-exposures, including heavy metals and psychosocial factors, on adolescent and young adult cardiometabolic health. The research aims to provide new insights on the role of physiological stress as a potential mechanistic...
This federal Project Grant award from the National Institute of Environmental Health Sciences (CFDA 93.113 Environmental Health) provides $637,553 to Rutgers, The State University of New Jersey to assess the toxicity, uptake, and biodistribution of environmentally relevant micro-nanoplastics (MNPs) and the role of intestinal inflammation. The key goals are to:
Develop and characterize five environmentally relevant gold core-plastic shell MNP formulations to enable accurate quantification...
This $207,700 Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program will fund research to identify the effects of cyanopeptide mixtures on human health and the environmental drivers of toxic metabolite production in cyanobacterial harmful algal blooms (cyanoHABs). The research will utilize field and laboratory studies, incorporating multi-omic and bioassay techniques, to redefine the concept...