This federal Project Grant award in the amount of $107,493, made by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), supports research at the University of Michigan focused on characterizing the joint effects of early life lead exposure and psychosocial co-exposures on physiological stress and cardiometabolic health across the life course.
The key objectives are to: 1) examine the combined impacts of early life and childhood heavy metal exposure, socioeconomic position, and home environment on adolescent cardiometabolic health, and 2) investigate the role of physiological stress as a mechanistic pathway linking these early life environmental and psychosocial co-exposures to young adult cardiometabolic outcomes. This research aims to identify modifiable risk and protective factors that can be targeted to improve long-term health for individuals exposed to lead early in life.