The Project Grant award R56ES034423 from the Department of Health and Human Services National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $445,500 to the University of Alabama at Birmingham (UAB) to study the role of extracellular vesicles (EVs) and exosomes as mediators of injury from inhaled exposures to toxic chemicals such as sulfur mustard and chlorine. The project aims to: (A) characterize EVs/exosomes derived from the bronchoalveolar lavage fluid...
This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under CFDA 93.310 - Trans-NIH Research Support program provides $235,500.00 to Rutgers, The State University of New Jersey to investigate the use of electrophilic fatty acids as a potential medical countermeasure for chlorine-induced lung injury. The key objectives are to: 1) pre-screen up to 55 electrophilic fatty acid compounds for their ability to inhibit macrophage activation in vitro, and 2)...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,386,000 to the University of Utah to develop an innovative "Extracellular Vesicle Tricorder" technology. This technology aims to enable population-level monitoring of the human exposome and its impact on health by analyzing proteins, DNA, RNA, and other analytes in circulating extracellular vesicles obtained from blood...
The National Institutes of Health (NIH) Office of the Director awarded a $226,464 Project Grant (CFDA 93.310 - Trans-NIH Research Support) to the University of Wisconsin System's Office of Sponsored Programs Division at the University of Wisconsin-Milwaukee. The grant supports research to develop medical countermeasures for chlorine exposure based on GABA(A) receptor targeting. The key objectives are to determine the therapeutic effects of nebulized and intramuscularly administered MIDD0301, a...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $756,875.00 to investigate the molecular mechanisms by which neutrophil extracellular traps (NETs) contribute to airway damage and infection in mucoobstructive lung diseases. The primary focus is on understanding how NETs impact lung epithelial cells, with a specific emphasis on NET-mediated cleavage of E-cadherin and the...
The University of Georgia Research Foundation, Inc. (UGA Research Foundation) was awarded a $501,482 project grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports research to investigate the function and potential therapeutic applications of extracellular vesicle-derived Clara cell protein 16 (EV-CC16) in treating gram-negative bacterial pneumonia. The project aims to further understand the role of...
This $203,974 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a research project to investigate the effects of normal and diseased extracellular matrix (ECM) on the self-renewal and differentiation of airway basal epithelial cells. The project leverages novel tools developed by the co-PIs, including "inside-out" airway organoids and ECM hydrogels derived from normal and...
This $600,761 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to understand the role of the NKG2D receptor and its ligands in driving lung inflammation and development of bronchopulmonary dysplasia (BPD) in preterm infants. The key objectives are to: 1) Investigate the contribution of NKG2D+ lung lymphocytes (gamma-delta T cells and NK cells) to LPS- and hyperoxia-induced lung...
This federal Project Grant award, valued at $2,241,717.00 and provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research aimed at defining the spatiotemporal profile and cellular heterogeneity of marginal zone B and B1 cell-specific protein (MZB1)+ B and plasma cell populations in the development of chronic rejection after lung transplantation. The overarching goal is to interrogate the mechanistic...
This $607,952 Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research at the University of Pittsburgh to investigate indole metabolites as novel danger signals that activate regulated cell death pathways in lung epithelial cells, which may contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). The key research objectives include...