Project Grant R01ES036487
- Federal Project Grant Award Summary Saint Louis University received a $556,651 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2028. The award supports research focused on developing transition metal photosensitizers with metal-metal bonds as an alternative to traditional noble metal-based photosensitizers. The project will deliver a novel class...
- Federal Project Grant Award Summary Saint Louis University received a $385,000 Project Grant award effective September 1, 2025, through August 31, 2028, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports fundamental research to characterize the functions of ATALKBH4, a putative DNA N6-adenine methylation (6MA) demethylase in plants. The project will advance understanding of 6MA and its...
- Federal Project Grant Award Summary Saint Louis University received a Project Grant award of $416,625 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 11, 2025, with completion targeted for July 31, 2027. The award funds the PTSOMICS project, which focuses on machine learning-driven discovery and analysis of polymorphic toxin and effector systems (PTSS). The project deliverables...
- Federal Grant Award Summary This Project Grant, awarded on April 23, 2026, by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), provides $1.40 million in funding to Michigan State University's Henry Ford Health + Michigan State University Health Sciences partnership through April 22, 2029. The award supports research investigating the mechanisms of lung toxicity resulting from skin exposure to vesicating agents,...
- Federal Grant Award Summary Saint Louis University received a $1.925 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through August 31, 2029. The award funds fundamental research investigating the structural dynamics of the human mitochondrial pyruvate carrier (MPC) during transport and inhibition mechanisms. The research employs Double Electron-Electron...
- Federal Project Grant Award Summary Saint Louis University received a $192,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 13, 2026 through January 31, 2028. The award supports research investigating the molecular mechanisms by which a specific genetic polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene—specifically the -2518 SNP-G...
- Federal Grant Award Summary The Washington University received a $410,520 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded April 1, 2026, with completion targeted for January 31, 2031. The award funds fundamental research investigating the molecular principles of intracellular electrochemistry, specifically examining how living systems establish and maintain buffering environments to...
- Federal Project Grant Award Summary Saint Louis University received a $259,125 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 1, 2026 through March 31, 2028. The grant funds investigator-initiated biomedical research to examine how altered neutrophil function contributes to poor disease outcomes in patients with comorbid diabetes mellitus and tuberculosis (TB). The...
- Federal Project Grant Award Summary The University of Alabama at Birmingham (UAB) received a $1.341 million Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 1, 2025, through August 31, 2028. The award funds a three-year research initiative investigating the mechanisms of delayed lung injury following exposure to trivalent arsenic chemical agents, including Lewisite, phenyl...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $731,827 Project Grant to J. David Gladstone Institutes, effective September 1, 2025 through June 30, 2030, under the Cardiovascular Diseases Research program (CFDA 93.837). The research project, "Mechanisms of Oxygen Toxicity," focuses on understanding how excess oxygen (hyperoxia) damages cellular tissue across multiple disease states, including hyperoxic lung injury,...
Saint Louis University received a $1.377 million Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective April 11, 2026 through April 10, 2029. The award funds research investigating the mechanisms of halogen gas toxicity, specifically examining how exposure to chlorine (Cl₂) and bromine (Br₂) gases produces electrophilic halogenated fatty aldehydes that target erythrocytes and mediate coagulopathy and end-organ injury. The research will characterize two mechanisms of platelet activation: direct activation by halogenated fatty aldehyde-glutathione (FALD-GSH) adducts and indirect activation following red blood cell hemolysis and release of stored FALD-GSH, with particular focus on CYSLT2 receptor involvement. The project's research deliverables include mechanistic elucidation of how FALD-GSH mediates platelet activation via the CYSLT2 receptor and development of a unifying mechanism explaining both Cl₂ and Br₂ gas toxicity. By identifying FALD-GSH as a novel agonist of platelet activation, this research aims to establish a common therapeutic target for countermeasure development against halogen gas exposure—a public health priority given the hazards of industrial accidents and chemical warfare involving these agents. The award supports basic science research conducted at Saint Louis University's Missouri facility over the three-year project period.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 4/8/26 |