This federal Project Grant award under the Environmental Health (CFDA 93.113) program from the National Institute of Environmental Health Sciences (NIEHS) provides $682,698 to Florida A & M University (FAMU) to investigate the mechanisms by which manganese (Mn) exposure induces neurotoxicity through the regulation of the Leucine-Rich Repeat Kinase 2 (LRRK2) protein in microglia. The project aims to elucidate how Mn increases LRRK2 expression and kinase activity, and how this leads to...
This $688,904 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to investigate the mechanisms linking developmental manganese (Mn) exposure, dopamine dysregulation, and the increased frequency of ADHD diagnoses. The research, conducted by Vanderbilt University Medical Center (VUMC) and sub-awardees Purdue University and Vanderbilt University, aims to deepen the understanding of...
This federal Project Grant award, funded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program, supports the South African Manganese Environmental Neurotoxic Effects Research (SMELTER) study. The $585,531 award, with a performance period from September 1, 2024 to June 30, 2029, aims to examine the neurological health effects associated with manganese exposure in a cohort of over 800 South African residents. The study involves...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $400,847.00 to Louisiana State University to conduct research on the role of noradrenergic signaling in mediating the impact of developmental lead exposure on stress-related behavioral disorders. The key focus is to examine how early-life lead exposure disrupts the regulation of the locus coeruleus noradrenergic neurons and leads to...
This Project Grant award for $448,383 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program will fund research to determine the impact of maternal ingestion of cyanotoxins on the development and function of the stress axis in offspring. The primary objectives are to: 1) Determine if sub-chronic maternal exposure to the cyanotoxin microcystin-LR disrupts the development of brain regions that control the stress...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $728,408 to investigate novel genetic variants that confer susceptibility to pesticide-induced Parkinson's disease. The research aims to biologically validate candidate gene variants associated with increased susceptibility, using human induced pluripotent stem cell-derived neuronal cultures and a mouse model of paraquat-induced...
The National Institute of Environmental Health Sciences (NIEHS) awarded a Project Grant under the Environmental Health (CFDA 93.113) federal grant program to the Regents of the University of Michigan in the amount of $292,368. The award, effective September 1, 2024 through March 31, 2026, will support research to "disentangle the drivers and dangers of toxic cyanobacteria biosynthetic heterogeneity in cyanobacterial harmful algal blooms (CyanoHABs)." The research aims to identify the...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $704,695 to The Roskamp Institute, Inc. to investigate the neurological effects of aerosolized red tide neurotoxins. The primary goals are to determine the dose-response relationship between aerosolized exposure to the neurotoxin brevetoxin and the development of neurological symptoms, as well as whether individuals with preexisting...
This federal Project Grant award of $822,643.00, awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund a research project to investigate how chronic exposure to common environmental neurotoxicants like lead, cadmium, and arsenic impact brain aging and the risk of late-onset Alzheimer's disease (LOAD). The researchers at Boston University Medical Campus, the prime awardee, will use innovative mouse models developed by the Model-AD Consortium to study...
This federal Project Grant award of $985,026 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to investigate the roles and mechanisms of epitranscriptomic regulation in the development and function of the mammalian nervous system, as well as the pathological consequences of disrupting these processes. The research program will utilize mouse models and human induced...