This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, will provide $622,235.00 to the University of Illinois to research the impact of developmental herbicide exposures on gut microbiome physiology and interactions with health. The project aims to define how interactions between herbicide exposure, the microbiome, and the host can contribute to increased adiposity and obesity. The research will...
This NSF Biological Sciences (CFDA 47.074) Project Grant award of $600,000 to Emory University will investigate how microbiome communities, which are communities of bacteria and other microbes that live in and on organisms, can resist change and transition to alternate states. The project will use the nematode worm Caenorhabditis elegans as a model host to better define the stability and properties of alternate microbiome states, as well as how factors like antibiotic treatment and host...
The National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) Federal Grant Program, awarded a $1,946,073 Project Grant to the University of Washington to characterize the impact of benzalkonium chloride (BAC) exposure on the gut microbiome and gut-liver interactions. The 5-year project aims to: Determine how BAC exposure affects gut microbiome diversity and function, and correlate changes in the microbiome with bile acid, sterol, and lipid...
The University of California, Davis has been awarded a $423,657 Project Grant (CFDA 93.113 - Environmental Health) from the National Institute of Environmental Health Sciences (NIEHS) to study the impact of neonatal exposure to per- and polyfluoroalkyl substances (PFAS) on the microbiota-gut-brain axis. The research aims to determine if neonatal PFOA exposure leads to long-term deficits in the microbiota-gut-brain axis, including impacts on gut physiology and behavior, as well as whether...
The National Institute of Environmental Health Sciences (NIEHS) awarded Nexilico, Inc. a $275,765 Project Grant (CFDA 93.113 - Environmental Health) to develop a predictive computational-experimental platform to characterize microbial biotransformation of xenobiotic compounds and identify naturally occurring gut microbial strains that can mitigate xenobiotic toxicity as novel probiotics. The project aims to provide cost-effective yet accurate predictions to identify microbial species capable...
The National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health (CFDA 93.213) program, awarded a $822,442 project grant to North Carolina State University to conduct research on the gut microbiome's production of terpenoids and carotenoids. The research aims to use a novel phage-based functional metagenomics approach and high-throughput screening to discover new terpene synthases and carotenoid modifying enzymes within...
The Regents of the University of California received a five-year, $2.4 million Project Grant from the National Science Foundation to support the research project "MIM: A Thermodynamic Theory of Microbiome Assembly, Adaptation and Evolution Evaluated Using Modular Microbial Environments" from October 1, 2021 through September 30, 2026. This grant is being administered under the NSF's Biological Sciences program (CFDA 47.074), which aims to advance the fundamental biological sciences and...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,140,912 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to the University of North Carolina at Chapel Hill. The 5-year grant, effective from August 1, 2024 to July 31, 2029, will support research to understand host-microbiome coevolution and genetic variation in immunity using an insect model system. The research program takes advantage of the pea aphid, an insect that reproduces...
The University of Nebraska was awarded a $649,927 Project Grant from the USDA National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (AFRI) program. The objective is to develop microbiota-based strategies that protect the host from cadmium (Cd) toxicity. The research will employ human microbiota-associated mice to determine the role of Cd tolerance of the gut microbiota and Cd-tolerant bacteria in mediating Cd accumulation and oxidative stress in host tissues....
The National Institute of General Medical Sciences (NIGMS) awarded a $1,338,750 Project Grant to Yale University to conduct research on how gut bacteria can influence host feeding behavior and microbiome assembly using the roundworm Caenorhabditis elegans as a model system. The project aims to develop tools and assays to study the molecular mechanisms by which gut microbes can manipulate host feeding decisions, with the goal of gaining insights that may apply to other host-microbe systems. Key...
This $2,166,750 project grant from the National Institutes of Health's National Institute of Environmental Health Sciences will fund research into the role of the gut microbiome in host adaptation to environmental xenobiotics. The University of California, Berkeley will explore how exposure to commonly used pesticides shapes the gut microbiome of the model organism C. elegans, and the long-term health consequences for the host. Researchers will characterize microbiome-assisted adaptation to better understand the mechanisms by which bacterial communities protect the host from toxic effects. They will identify bacteria that confer pesticide resistance, examine the adaptation process over time, and evaluate impacts on metabolism, immunity and lifespan. This work aims to foster understanding of human health effects from pesticide exposure, as called for under the Environmental Health program. Insights gained could lead to identifying hazards and improving risk assessments of chemicals that are poorly understood but associated with disease.