This $646,476 Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program will support research at the University of California, Los Angeles (UCLA) to investigate how environmental exposure to inorganic arsenic impacts epigenetic regulation and transgenerational inheritance. The overarching goal is to understand how arsenic triggers epigenetic changes that can resist developmental reprogramming in...
This federal Project Grant award from the National Institute of Environmental Health Sciences (CFDA 93.113 Environmental Health) provides $157,500 to the Regents of the University of California at Riverside to pilot studies on the potential link between prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and autism spectrum disorder (ASD) risk. The research aims to examine how PFAS exposure during development may interact with genetic factors to influence fetal neurodevelopment and...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program provides $379,504 to the University System of New Hampshire's Keene State College to conduct research on the tissue-specific development of toxicity in response to transgenerational chronic arsenic exposures. The key objectives are to: (1) detect tissue-specific uptake of arsenic in response to transgenerational chronic exposure; (2)...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $224,900 to Emory University to investigate determinants of perinatal lead exposure and its association with preterm birth among the Atlanta African American Maternal Child Cohort. The 4-year project aims to: 1) test hypotheses about socioeconomic and environmental factors associated with higher maternal lead levels, 2) examine the...
This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $222,750 to the University of Alabama at Birmingham (UAB) to define the molecular target of arsine gas-induced acute kidney injury and associated morbidity. The key objectives of this 2-year award are to: 1) characterize a mouse model of arsine toxicity, including dose- and time-dependent responses, biomarkers of acute kidney injury, and evaluation of multi-organ...
The National Institute of Environmental Health Sciences (NIEHS) awarded a $639,686 Project Grant under the Environmental Health (CFDA 93.113) program to the University of Cincinnati. The grant will fund a longitudinal study investigating the impact of fluoride exposure during critical developmental windows, from prenatal to early childhood, on cognition, neurobehavior, and brain structure in adolescence. The study will leverage existing resources from two well-characterized birth cohorts in...
This three-year, $4.84 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at The Johns Hopkins University to investigate the neurological effects and cumulative risk of neurodegenerative disease from exposure to metal mixtures. Specifically, the researchers will examine the biological mechanisms by which exposure to mixtures of lead, arsenic, cadmium, and chromium during adulthood and early development cause...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, provides $695,853 to the Arkansas Children's Research Institute (ACRI) from December 1, 2024 to November 30, 2029. The project will investigate the impact of prenatal and postnatal exposure to per- and polyfluoroalkyl substances (PFAS) on children's development, examining the role of placental function and the potential protective...
This federal Project Grant award, totaling $2,004,633.00, was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research to investigate the role of dysregulated RNA metabolism in maternal diabetes-induced neural tube defects (NTDs), which are a common birth defect. The research aims to determine how maternal diabetes represses the...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $127,266 to The Regents of the University of Colorado to investigate the relationship between embryonic glucose homeostasis and neural tube closure. The key objectives are to: 1) Examine the role of the insulin receptor substrate 1 (IRS-1) protein in regulating cellular glucose consumption dynamics...