Project Grant R01EB039074
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Davis $615,615 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop next-generation whole-body positron emission tomography (PET) scanners with enhanced spatial resolution and timing performance. The research aims to achieve sub-2 millimeter spatial resolution and approximately 8 cubic millimeter...
- The National Institute of Biomedical Imaging and Bioengineering awarded $161,000 to the University of California, Davis on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop an affordable dynamic total-body positron emission tomography (TB PET) imaging system using sparse detector architectures. The research addresses cost barriers to TB PET adoption by reducing scintillator material and readout electronics...
- The National Institute of Biomedical Imaging and Bioengineering awarded The Regents of the University of California, operating Lawrence Berkeley National Laboratory, $312,165 on June 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop Time-of-Flight Multi-Photon Emission Tomography (TOF-MPET) for direct imaging of therapeutic radionuclides in cancer treatment. The project addresses limitations in current imaging...
- The National Institute of Biomedical Imaging and Bioengineering awarded $2.238 million to the University of California, Davis on May 12, 2026 under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and evaluate whole-body parametric imaging methods for pediatric positron emission tomography (PET) imaging. The project develops a relative Patlak plot technique enabling quantitative kinetic imaging in pediatric cancer...
- The National Institute of Biomedical Imaging and Bioengineering awarded The General Hospital Corporation (Massachusetts General Hospital) $100,000 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop a quantum-inspired computational framework for advanced positron emission tomography (PET) imaging. The project addresses clinical gaps in PET's ability to detect small lesions, distinguish subtle treatment effects, and reduce radiation dose. The framework...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Southern California $663,498 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a modular microscale platform for rapid 18F-radiopharmaceutical production via click chemistry and droplet radiochemistry. The project addresses barriers in positron emission tomography tracer development by creating a...
- The National Institute of Biomedical Imaging and Bioengineering, a component of the Department of Health and Human Services National Institutes of Health, awarded $184,063 to the University of Texas at San Antonio on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development of forced-dimerization activated photoacoustic aptamer switch sensors (FDA-PASS), optical probes designed to enable...
- The National Institute of Biomedical Imaging and Bioengineering, part of the Department of Health and Human Services, awarded $329,058 to Actinia Inc. on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286, Assistance Listing program R43EB038821) to develop high-resolution energy-integrating computed tomography scanners using direct-conversion detectors made from cesium lead bromide. Current X-ray CT instruments...
- The National Institute of Biomedical Imaging and Bioengineering awarded $447,728 to the University of California, Santa Barbara on August 5, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to design new bifunctional chelators that enable diagnostic imaging and targeted alpha particle therapy for cancer treatment. The project addresses two key limitations in alpha particle emitter-based radiopharmaceutical therapy: the...
- Federal Cooperative Agreement Summary California Institute of Technology (Caltech) received a $3.18 million Cooperative Agreement from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) for the period September 1, 2025 through August 31, 2027. The award funds research to develop next-generation photoacoustic computed tomography (PAT) technology that significantly advances deep-tissue optical imaging capabilities. The...
The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Davis $701,020 on August 10, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop positronium lifetime tomography as a quantitative imaging modality for mapping tissue microenvironment in vivo. The project advances positronium lifetime tomography (PLT) as a novel diagnostic imaging technique complementary to positron emission tomography. PLT measures ortho-positronium lifetime before annihilation, providing information about local chemical environment including oxygen concentration, free radicals, and tissue composition, with applications as a biomarker for hypoxia and cellular stress in cancer, cardiovascular, and neurodegenerative diseases. A key advantage is that PLT utilizes data readily acquirable on existing time-of-flight PET scanners during routine scans, requiring no new hardware or additional scanning. The award funds development of the first robust and fully quantitative PLT framework and demonstration of its performance using the PennPET Explorer, a total-body time-of-flight PET scanner. Work includes enhancement of statistical efficiency in lifetime image reconstruction, incorporation of advanced regularization, and comprehensive corrections for scatter, randoms, attenuation, and normalization. Optimized acquisition protocols will be developed through Monte Carlo simulations and phantom studies. Validation will occur in large animal models (pigs) under controlled hypoxic conditions using multiple radioisotopes, with ortho-positronium lifetime measurements compared against direct oxygen readings from invasive probes. Following preclinical validation, human imaging studies will be conducted. Performance takes place in Davis, California. The award period runs through July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $701.0k | 8/10/26 |