Project Grant R01EB039679
- The National Institute of Biomedical Imaging and Bioengineering awarded The Regents of the University of California, operating Lawrence Berkeley National Laboratory, $312,165 on June 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop Time-of-Flight Multi-Photon Emission Tomography (TOF-MPET) for direct imaging of therapeutic radionuclides in cancer treatment. The project addresses limitations in current imaging...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded $855,000 to UT-Battelle LLC (Oak Ridge National Laboratory) on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop structurally expanded bifunctional chelators for targeted radiopharmaceuticals in cancer diagnosis and treatment. The award funds research to redesign chelating frameworks that bind radiometal cations and attach targeting vectors to cancer...
- The National Cancer Institute awarded The Regents of the University of California, San Francisco $420,943 on August 6, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop and evaluate alpha-particle radioimmunotherapy combined with antibody-drug conjugates for pancreatic ductal adenocarcinoma treatment. The work establishes an alkaline phosphatase placental-like 2 (ALPPL2)-directed therapy platform exploiting restricted ALPPL2 expression in pancreatic cancer to concentrate...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Southern California $663,498 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a modular microscale platform for rapid 18F-radiopharmaceutical production via click chemistry and droplet radiochemistry. The project addresses barriers in positron emission tomography tracer development by creating a...
- The National Institute of General Medical Sciences awarded $430,109 to The Regents of the University of California, operating Lawrence Berkeley National Laboratory, on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop deeply subwavelength near infrared imaging technology using avalanching nanoparticles. The project addresses fundamental limitations of live-cell optical microscopy by creating avalanching nanoparticles (ANPs) that upconvert incident...
- The National Cancer Institute awarded The Regents of the University of California, San Francisco $640,466 on June 1, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop covalent protein radiopharmaceuticals for targeted radionuclide therapy in cancer treatment. The project, funded through a Project Grant (R01CA309883), addresses a fundamental challenge in radiopharmaceutical design: balancing tumor uptake efficacy with safety by minimizing radiation exposure to normal...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Davis $615,615 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop next-generation whole-body positron emission tomography (PET) scanners with enhanced spatial resolution and timing performance. The research aims to achieve sub-2 millimeter spatial resolution and approximately 8 cubic millimeter...
- The National Institute of Biomedical Imaging and Bioengineering awarded $161,000 to the University of California, Davis on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop an affordable dynamic total-body positron emission tomography (TB PET) imaging system using sparse detector architectures. The research addresses cost barriers to TB PET adoption by reducing scintillator material and readout electronics...
- The National Cancer Institute awarded the University of California, Davis $409,141 on June 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop contrast-enhanced perfusion CT imaging as an alternative to current liver radioembolization workup procedures. The project addresses imaging optimization for selective internal radiation therapy (SIRT), a catheter-based treatment for liver cancer using radioactive yttrium-90 microspheres. Current clinical practice...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Santa Barbara $582,137 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop electrochemical aptamer-based sensors for long-duration, real-time molecular measurements in living tissue. The research aims to extend the in vivo operational lifespan of electrochemical aptamer-based sensors beyond their...
The National Institute of Biomedical Imaging and Bioengineering awarded $447,728 to the University of California, Santa Barbara on August 5, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to design new bifunctional chelators that enable diagnostic imaging and targeted alpha particle therapy for cancer treatment. The project addresses two key limitations in alpha particle emitter-based radiopharmaceutical therapy: the lack of diagnostic capability (gamma or positron emissions) for imaging, and the scarcity of suitable chelators compatible with alpha emitters' unconventional coordination chemistry. Supply chain constraints on promising alpha isotopes such as actinium-225 compound these barriers. The research will develop chelators simultaneously compatible with diagnostic radionuclides (aluminum, gallium, and scandium coupled to fluorine-18 for positron emission tomography or gamma imaging) and more readily available alpha-emitting isotopes, particularly lead-212. This dual-compatibility approach supports theranostic applications—combining therapy with diagnostic visualization—while circumventing sourcing limitations. Performance occurs in Santa Barbara, California. The period of performance extends from August 5, 2026 through July 31, 2030. The award is a Project Grant, the standard assistance type for individual research proposals under NIBIB's portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $447.7k | 8/5/26 |