Project Grant R01DK148878
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Regents of the University of Minnesota $161,275 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, assistance type: Project Grant) to investigate the impact of short chain fatty acids on calcium regulatory pathways in kidney stone formers. The research employs a multi-omics approach to delineate the interplay between the microbiome, short chain fatty acids...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $728,742 to Indiana University Indianapolis on February 5, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate interactions between calcium oxalate crystals, bacteria, and host immune factors in kidney stone formation. The recipient will measure how stone matrix proteins and bacteria interact to promote stone formation and will study biofilm-related genes...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Regents of the University of Minnesota $676,905 on February 16, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, R01DK143274). The award funds basic research on stromal regulation of pathological bone remodeling in diabetes. The project tests whether genetic and pharmacological elevation of O-linked N-acetylglucosamine (O-GlcNAc) signaling prevents diabetic...
- Federal Project Grant Award Summary The University of Chicago received a $984,000 Project Grant award dated September 4, 2025, from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The three-year research initiative, concluding September 3, 2028, will investigate a novel preventive treatment for recurrent idiopathic calcium phosphate kidney stones using sodium glucose...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Regents of the University of Minnesota $694,934 on May 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate modulation of interoception by TRPV1-expressing renal afferent nerves. The research addresses gaps in understanding afferent renal nerve location, origin, central nervous system interaction, and functional properties under physiological and...
- The National Institute of Diabetes and Digestive and Kidney Diseases, an institute within the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Michigan $690,854 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research to identify molecular and genetic mechanisms that determine and maintain kidney epithelial cell states in normal physiology and in...
- The National Institute of Diabetes and Digestive and Kidney Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded $674,691 to the Trustees of Indiana University (doing business as Indiana University Indianapolis) on August 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research investigating alternative splicing of uromodulin (AS-UMOD) as a protective mechanism against...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Regents of the University of Minnesota $479,325 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research defining choline metabolism in metabolic health and its relationship to metabolic-associated liver dysfunction. The recipient will conduct three sets of studies examining how obesity disrupts choline's contribution to the...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Massachusetts General Hospital $251,626 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic research on c-kit receptor signaling in kidney collecting duct function. The research investigates the role of c-kit receptor signaling in modulating collecting duct epithelial cell composition and function. The project uses c-kit "sash" mice...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Veterans Medical Research Foundation of San Diego $383,098 on September 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will conduct research into kidney tubule dysfunction in APOL1-associated chronic kidney disease, with focus on developing and validating tubular biomarkers that capture kidney functions—nutrient reabsorption and toxin...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded $821,457 to the Regents of the University of Minnesota on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant R01DK148878). The research investigates uromodulin polymerization and peptides as mechanisms in calcium oxalate kidney stone pathogenesis. The study leverages a genetic variant discovered in dogs that affects uromodulin function and kidney stone risk to elucidate the cellular and molecular pathways in humans. The project will test whether uromodulin polymerization status and peptides regulate renal solute transporters and channels (Aim 1), modulate the renal inflammatory response to crystallization (Aim 2), and will identify abnormalities in urinary uromodulin polymerization and peptide excretion in human idiopathic calcium oxalate stone formers compared to age- and sex-matched stone-free controls, integrating genetic data on uromodulin variants (Aim 3). Work is performed in Minneapolis, Minnesota. The period of performance runs from September 1, 2026, through May 31, 2031. This project grant supports basic and clinical biomedical research aimed at improving understanding of disease mechanisms and informing prevention and treatment strategies for kidney diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $821.5k | 8/28/26 |