Project Grant R01DK145735
- Federal Project Grant Award Summary Massachusetts General Hospital received a $133,328 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 20, 2025 through September 19, 2026. The award supports research investigating the distinct roles of PPM1D and TP53 mutations in hematopoietic stem cells and clonal hematopoiesis (CH)—the...
- Federal Project Grant Award Summary Boston Children's Hospital received a $469,042 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 1, 2025, through August 31, 2027. The award funds the transformation and optimization of a human induced pluripotent stem cell (iPSC)-derived bone marrow organoid model for studying hematopoiesis. The...
- Federal Project Grant Award Summary Massachusetts General Hospital received a $661,694 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on September 3, 2025. The award, with a completion date of June 30, 2029, funds research to understand the non-canonical role of FANCD2 (Fanconi Anemia Complementation Group D2) as a transcriptional regulator in kidney...
- Federal Grant Award Summary Boston Children's Hospital received a $154,860 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded August 1, 2025, with completion anticipated by May 31, 2028. The grant funds research investigating the mechanisms of clonal competition in age-related clonal hematopoiesis (CH), a condition where hematopoietic stem cells...
- Federal Project Grant Award Summary The Children's Hospital Corporation, operating as Boston Children's Hospital, received a $801,000 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was obligated on September 15, 2025, with a completion date of July 31, 2030. This research initiative, conducted at the institution's Boston, Massachusetts facility,...
- Federal Grant Award Summary This Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), provides $453,750 in federal funding to Massachusetts General Hospital for basic biomedical research investigating the interconnections between one-carbon metabolism, S-adenosyl-methionine (SAM) availability, and chromatin methylation. The research award, effective June 1, 2025 through April 30, 2030, will...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Massachusetts General Hospital a $813,961 Project Grant effective February 1, 2026, through November 30, 2030, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research focuses on elucidating bone morphogenetic protein (BMP) 2 and BMP6 ligand formation and function in development and iron homeostasis. The project investigates critical...
- Federal Project Grant Award Summary Harvard Medical School received an $830,414 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective August 13, 2025, with a completion date of June 30, 2030. The award supports research focused on identifying and characterizing microbiome-derived sulfated metabolites and their biological effects on human...
- Federal Project Grant Award Summary Massachusetts General Hospital received a $110,865 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective April 1, 2026 through March 31, 2031. The award funds investigator-initiated research examining c-kit receptor signaling in the modulation of kidney collecting duct function. The research aims to elucidate the...
- Federal Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $740,581 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded April 1, 2026, with completion targeted for January 31, 2031. The grant funds basic biomedical research investigating the niche regulation of gastric epithelial cell differentiation, specifically examining how...
Massachusetts General Hospital received a $761,577 project grant awarded March 15, 2026, by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports fundamental research investigating the roles of histone modifications—specifically H3K4 methylation (H3K4me) and H3K27 methylation (H3K27me)—in regulating hematopoiesis (blood cell development). The research employs novel histone mutant transgenic tools to elucidate how these epigenetic marks function individually and in combination to control gene expression during blood cell maturation and differentiation. The deliverables under this award include research findings on the molecular mechanisms governing hematopoietic stem cell maintenance and terminal maturation of blood cell progenitors, with particular focus on how H3K4me opposes repressive H3K27me marks at bivalently-marked genes. The project extends through January 31, 2030, and is expected to generate insights with clinical relevance regarding chromatin regulation in mammalian tissue homeostasis. Research will be conducted at Massachusetts General Hospital's Boston, Massachusetts facility under the institution's Research Management Division.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $761.6k | 3/2/26 |