Project Grant R01DK144830
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Texas Woman's University $133,175 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of DHRS9 in diet-induced obesity and diabetes. The research project will define how DHRS9 modulates insulin sensitivity under high-fat diet conditions across sexes and determine whether retinoid or specialized pro-resolving mediator (SPM)...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $1.610 million on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of the cystic fibrosis transmembrane receptor (CFTR) in dietary fatty acid transport in the small intestine. The research, led by Principal Investigator Alison B. Kohan and co-investigator C.A. Hodges, will test clinically relevant...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $676,279 to The University of Texas Southwestern Medical Center on January 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify metabolic regulators of hepatic phosphatidylcholine synthesis. The research addresses genetic regulation of phosphatidylcholine (PC) metabolism in response to metabolic stress and its relevance to metabolic dysfunction-associated...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas Southwestern Medical Center $694,250 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to explore a novel pathway for ApoB mRNA degradation in regulating VLDL secretion and steatotic liver disease. The recipient will conduct basic biomedical research identifying mechanisms by which the HELZ2 gene regulates hepatic lipid secretion...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Texas Health Science Center at Houston $154,332 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of kynurenine-aryl hydrocarbon receptor signaling in cholestatic liver injury. The research examines how the kynurenine pathway and aryl hydrocarbon receptor activation regulate reactive oxygen species accumulation,...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded New York University $1,677,898 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop fat and iron-corrected quantitative MRI T1 mapping as a non-invasive biomarker for evaluating chronic liver disease, particularly metabolic-associated steatohepatitis (MASH). The project addresses the clinical need for non-invasive assessment of liver pathology...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Ohio State University $807,563 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for Project Grant R01DK149654. The award funds development of potent, selective Type III CD38 inhibitors as first-in-class therapeutics to reduce ischemia-reperfusion injury in liver transplantation. Current CD38 inhibitors lack topology selectivity, requiring doses over...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $807,500 on August 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project, titled "Decoding the Logic of Metabolite Pool Size Control," develops an integrated metabolic control discovery platform to understand the molecular mechanisms that regulate metabolite concentrations in cells. The research will systematically discover molecular...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Weill Medical College of Cornell University $109,652 on September 15, 2025, for research under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will conduct basic biomedical research investigating the regulation of mitochondrial lipid homeostasis by mechanistic target of rapamycin complex 1 (MTORC1). The research employs quantitative proteomic analysis and CRISPR/Cas9...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $1.479 million on June 15, 2026, to investigate the role of hepatocyte nuclear receptor 4 alpha (HNF4A) as a mediator of environmental risk factors in inflammatory bowel disease (IBD). The research will examine how HNF4A isoforms regulate intestinal barrier function, mucus production, brush border maintenance, and ion transport, and how the...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Case Western Reserve University $551,915 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate molecular factors controlling vitamin A uptake homeostasis. The research clarifies the roles of dehydrogenase/reductase 3 (DHRS3) and the transcription factor ISX in vitamin A homeostasis and their implications for lipid metabolism through three specific aims. Aim 1 investigates DHRS3's role in postnatal vitamin A homeostasis and beta-carotene conversion using conditional DHRS3 floxed mice, generating global, hepatocyte-specific, and enterocyte-specific knockouts. Mice will be fed diets with varying concentrations of preformed vitamin A and provitamin A, with retinoid and carotenoid concentrations measured using high-performance liquid chromatography (HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Retinoid signaling activity will be assessed in these mice compared to controls. Aim 2 explores the enterohepatic pathway regulating provitamin A metabolism. The award period runs through May 31, 2030, with place of performance in Cleveland, Ohio. Case Western Reserve University's Office of Research Administration serves as the recipient, operating in affiliation with University Hospitals of Cleveland.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $551.9k | 8/17/26 |