Project Grant R01DK143623
- This $109,076 Project Grant was awarded on July 1, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Weill Medical College of Cornell University to investigate the structural basis and pharmacological inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which plays a key role in the development and...
- The federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to understand the mechanisms linking the cystic fibrosis transmembrane conductance regulator (CFTR) gene to dysregulated barrier function, insulin receptor function, and glucose transport in the lungs of cystic fibrosis (CF) patients. The $730,494 award to Emory University, with a sub-award to Vanderbilt University Medical Center, aims to investigate...
- This Project Grant award of $613,558 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports Genetobe Inc., a Michigan-based biotechnology company, in developing novel, selective sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor compounds as an adjunctive therapy for cystic fibrosis (CF) associated metabolic disorders, including CF-associated liver disease and CF-related diabetes. The...
- This federal Project Grant award of $737,034.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The goal of this 5-year research project, with a start date of September 1, 2025, is to identify new regulatory inputs that control the biosynthesis of coenzyme A (CoA) in response to the metabolic state of cells and tissues, especially the kidney and liver. The...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $280,122 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Eldec Pharmaceuticals, Inc. in Chapel Hill, NC. The grant supports the development of a novel peptide therapeutic, ELD607, to treat cystic fibrosis-related diabetes (CFRD). The funding will enable Eldec Pharmaceuticals to further research and evaluate ELD607, an antagonist that inhibits the...
- This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research focused on understanding the mechanisms that regulate lipid flux in cells and animals, and how crosstalk between gut immune cells and the absorptive epithelium impacts metabolic disease. The $761,399 award, effective September 1, 2025 through June 30, 2030, will...
- This $2,971,227 federal Project Grant, awarded on September 4, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of fatty acids in regulating cellular metabolism and protein synthesis in the context of fasting, inflammation, and metabolic diseases. The research aims to uncover novel signaling pathways through which fatty...
- This $168,252 federal Project Grant awarded on September 15, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at Trustees of Boston University (DBA Boston University Medical Campus) to study the molecular mechanisms of nuclear receptor corepressors NCOR1 and SMRT and their role in regulating metabolism via actions in the intestine. The overarching goal is to expand...
- This $128,286 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research into the mechanisms of renal lipotoxicity and its contribution to the development of chronic kidney disease (CKD). The principal investigator will investigate the protective role of the FAF2 gene knockout in mitigating palmitate-induced lipotoxicity in...
- The federal Project Grant award titled "Carbonic Anhydrase Mediated Regulation of Microtubule Dynamics and Infection in Cystic Fibrosis" is funded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) in the amount of $163,080. The award, with a period of performance from September 1, 2025 to August 31, 2030, aims to investigate how impaired microtubule dynamics and intracellular transport, exacerbated by reduced carbonic anhydrase expression,...
This $812,621 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to decipher the role of the cystic fibrosis transmembrane receptor (CFTR) in dietary fatty acid transport within the small intestine. The Principal Investigator is Alison B. Kohan, with Co-Principal Investigator CA Hodges. The project aims to use novel surgical models and primary intestinal organoids to investigate how CFTR dysfunction inhibits the trafficking of dietary fats across the intestinal epithelial membrane, which contributes to the severe malnutrition and low body weight observed in cystic fibrosis patients, even with modulator therapy. The research outcomes could have a significant impact on understanding and potentially reversing the persistent nutritional defects experienced by cystic fibrosis patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $812.6k | 9/8/25 |