Project Grant R01DK144793
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $231,270 to The Trustees of Columbia University in the City of New York to conduct large-scale rare variant analyses across major biobanks involving 1 million participants. The goal is to identify rare genetic variants and genes associated with chronic kidney disease (CKD), as well as develop and integrate...
- This $223,176 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to characterize the role of apolipoprotein L1 (APOL1) copy number variations (CNVs) in kidney disease susceptibility among African Americans. The research, conducted by Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, MA, aims to: 1) develop a computational...
- This $659,358 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) investigating the genetic and biological mechanisms underlying kidney disease associated with APOL1 risk variants, particularly focused on the relationship between APOL1 gene dose and kidney...
- This $128,286 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research into the mechanisms of renal lipotoxicity and its contribution to the development of chronic kidney disease (CKD). The principal investigator will investigate the protective role of the FAF2 gene knockout in mitigating palmitate-induced lipotoxicity in...
- This Project Grant award for $124,284 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) will support research conducted by Weill Medical College of Cornell University. The key objectives are to: Develop a super-resolution deep learning framework to generate high-resolution 3D MRI volumes for enhanced monitoring of Autosomal Dominant Polycystic Kidney Disease (ADPKD), incorporating multiple...
- This $243,750 Project Grant was awarded on September 5, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the role of the protein DCLK1 in regulating the DNA damage response in proximal tubule cells, which are important mediators of chronic kidney disease (CKD). The research aims...
- This federal Project Grant award of $342,002.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at Western Michigan University Homer Stryker M.D. School of Medicine (WMED) to develop novel cellular tools for studying the regulation of the PKD1 gene in autosomal dominant polycystic kidney disease (ADPKD). The research aims to...
- This $400,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the earliest events in podocyte injury in collagen IV nephropathies. The goal is to investigate how processing of mutant collagen IV proteins injures podocytes at early stages, leading to chronic kidney disease and renal failure. The research uses...
- This $728,513 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a renal quantitative susceptibility mapping (QSM) technique for reliable detection and quantification of hemorrhagic cysts as a prognostic biomarker of kidney function decline in autosomal dominant polycystic kidney disease (ADPKD). The key objective is to leverage QSM...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $200,000.00 to New York University School of Medicine to conduct a case-cohort study investigating novel determinants of risk for living kidney donors. The key objectives are to: 1) use qualitative research to inform recruitment strategies and messaging to maximize participation of...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $739,540 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Trustees of Columbia University in the City of New York for the development and validation of a third-generation polygenic score (GPS) for chronic kidney disease (CKD). The goal is to improve personalized risk prediction and accelerate the clinical implementation of polygenic prediction in nephrology by addressing key gaps, including enhancing the predictive properties of the GPS, improving cross-ancestry transferability, and evaluating GPS performance across diverse clinical contexts. The project period runs from September 1, 2025 through June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $739.5k | 9/5/25 |