Project Grant K01DK144651

The National Institute of Diabetes and Digestive and Kidney Diseases awarded New Mexico State University $146,070 on September 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to fund basic research into the role of fibroblast-derived lysyl oxidase in arteriovenous fistula maturation failure.

The research will elucidate the molecular and cellular mechanisms by which lysyl oxidase upregulation increases the risk of arteriovenous fistula failure in patients with chronic kidney disease. Up to 40 percent of arteriovenous fistulas currently require endovascular or surgical intervention to address stenosis, which impairs their function for hemodialysis. The award aims to identify novel therapeutic targets to prevent or reduce fistula failure and support the principal investigator's career development toward a tenure-track faculty position in the vascular division of the Department of Surgery at the Miller School of Medicine, University of Miami.

Performance occurs in Miami, Florida, with a period of performance through July 31, 2031. The program supports extramural basic and clinical biomedical research improving understanding of disease mechanisms and leading to improved prevention, diagnosis, and treatment of diabetes, digestive, and kidney diseases.