Project Grant R01DK144214
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Leland Stanford Junior University $630,654 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate how intestinal tissue manages the tradeoffs of injury-accelerated cell differentiation. The project combines physiological injury of the Drosophila adult intestine with in vivo live imaging and cell lineage tracing to elucidate how accelerated...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Leland Stanford Junior University $782,886 on February 18, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support research on obesity control through an appetite-suppressing peptide. The research addresses the urgent need for new metabolies, including obesity and associated metabolic disorders. Work is performed in Palo Alto, California with a period of...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Leland Stanford Junior University $784,530 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to characterize the cellular and molecular architecture of the enteric nervous system under homeostatic and perturbed conditions. The recipient will develop and apply an integrated spatial multi-omics analytical workflow to study the enteric nervous system's...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Leland Stanford Junior University $2,404,071 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct biochemical and structural studies of phosphotriesterase-related (PTER), an orphan mammalian metabolic enzyme linked to body mass index and obesity. The award funds research to elucidate the structural basis for PTER catalysis and substrate...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Dana-Farber Cancer Institute, Inc. $740,581 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to fund basic research on niche regulation of gastric epithelial cell differentiation. The award funds investigation of how distinct stomach epithelial cell types—pit, isthmus, neck, and chief cells—arise from a common multipotential progenitor and are regulated by...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Leland Stanford Junior University $796,068 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic biochemical and physiologic research on the beta-hydroxybutyrate (BHB) shunt, a newly identified third metabolic pathway for BHB that influences energy balance and ketosis-associated weight loss. The research will determine the...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded California Institute of Technology $661,126 on August 21, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Assistance Listing Project Grant R01DK149061). The award funds bacterial metatranscriptomics research aimed at resolving contributions of host and microbial pathways to human health and disease. Tissue-associated microbes play fundamental roles in shaping host...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $178,000 to Beckman Research Institute of The City of Hope on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate how the native pancreatic microenvironment regulates human islet cell function in health and type 1 diabetes. The research employs human pancreatic tissue slices to preserve native cellular architecture and directly compares hormone...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Los Angeles $128,235 on September 13, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research to discover mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD) through single nucleus RNA-sequencing analysis of cell-type and cellular subtypes in subcutaneous adipose tissue, visceral adipose...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $798,039 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate self-organization in the intestinal epithelium. The award funds research into how enterocytes adopt specialized functions along the villus axis through a process called zonation. The project challenges conventional understanding by hypothesizing that...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Leland Stanford Junior University $611,189 on September 3, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the molecular mechanisms of epithelial symmetry breaking and repair. The research examines the roles of E-cadherin and PAR-3 proteins in establishing apical-basolateral polarity within epithelial tissues. The study focuses on how unpolarized epithelial primordia generate polarity de novo, with emphasis on the formation and function of local polarity complexes that cluster these proteins at cell contacts before delivery to the future apical surface. The research addresses mechanisms poorly understood in vivo and aims to improve understanding of processes central to human health, as failures in epithelial polarization can lead to tissue malfunction, digestive disease, embryonic lethality, or birth defects. Work is performed in Palo Alto, California with a period of performance extending from September 3, 2026 to May 31, 2030. The award is structured as a Project Grant, the primary assistance type under NIDDK's extramural research program supporting basic and clinical biomedical research that advances prevention, diagnosis, and treatment of diabetes, digestive, and kidney diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $611.2k | 9/3/26 |