The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $153,266 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Washington University's Office of Sponsored Research Services Division. This 5-year award, effective March 1, 2025, will fund research led by Principal Investigator Samantha Adamson, M.D., Ph.D., to define the mechanisms of paracrine signaling mediated by primary cilia in pancreatic beta cells. The project aims to elucidate the role of the TULP3 protein in trafficking the somatostatin receptor to beta cell cilia, and the contribution of calcium signaling within the cilia versus the cell cytosol in response to somatostatin. This research seeks to provide new insights into beta cell dysfunction and potential cilia-targeted therapies for diabetes.
Generated 3/18/25, 3:15 AM