This $126,480 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research at the University of California, Davis to investigate the role of the signaling protein 14-3-3-z in regulating communication between alpha and beta cells in the pancreatic islet. The goal is to shed light on new mechanisms underlying islet cell crosstalk and its impact on islet function, which could open new avenues for understanding and treating type 2...
This federal Project Grant award of $444,867.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the UPR transducer XBP1 in pancreatic beta cell survival and function under metabolic stress. The research will use a novel mouse model to elucidate the pathological role of XBP1s in beta cell integrity under metabolic stress, in order to...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $1,948,235 to Duke University to conduct research on alpha-to-beta cell communication and its role in insulin secretion and glucose homeostasis. The project will utilize preclinical studies in human islets as well as clinical studies in human subjects to investigate how alpha...
This $698,646 federal Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to study the functional and disease relevance of distinct pancreatic beta-cell subtypes, with a focus on understanding their epigenetic regulation and relationship to type 2 diabetes (T2D). The research will use novel single-cell epigenomic tools, conditional...
This Project Grant award of $240,725.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will fund research at the University of Iowa to investigate how proinflammatory cytokines affect pancreatic beta-cell Golgi structure and function in the context of type 1 diabetes. The research aims to understand the role of nitric oxide and the Golgi structural protein GRASP55 in driving Golgi remodeling...
This federal Project Grant award of $706,199 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to uncover the mechanisms of NAD depletion in obesity-induced pancreatic beta cell dysfunction and test strategies to restore beta cell mass and function in type 2 diabetes models. The award aims to define changes in NAD biosynthesis and degradation pathways...
This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the molecular mechanisms by which the bacterial protein Beta-cell Expansion Factor A (BEFA) induces proliferation and metabolic maturation of pancreatic beta cells. The $146,829 award, effective from June 2025 through December 2027, will be used by the...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) provides $267,310 to Purdue University from August 2024 to February 2028 to support research on the role of G protein-coupled estrogen receptor (GPER) signaling in maintaining beta cell identity and function. The research aims to define the relationship between impaired store-operated calcium entry (SOCE) and GPER expression/localization, and the role of GPER in beta cell...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,349,491 to The Trustees of the University of Pennsylvania to conduct research on reprogramming glutamine metabolism in pancreatic beta cells. The research aims to uncover the mechanisms by which the transaminase GPT2 promotes beta cell dysfunction and death, and elucidate how GPT2...
This Project Grant award, ID R01DK140088, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $641,794 grant awarded to the Beckman Research Institute of the City of Hope will fund research to elucidate the mechanisms that protect pancreatic beta cells from DNA damage during growth and adaptation, in order to maintain beta cell homeostasis and prevent beta...