Project Grant R01DK144166
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Icahn School of Medicine at Mount Sinai $168,000 on May 7, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct research targeting ChREBPβ for beta-cell protection in Type 1 diabetes. The research characterizes the contribution of ChREBPβ (carbohydrate-responsive element-binding protein B), a stress-inducible transcription factor, to beta-cell dysfunction in...
- Summary of Federal Project Grant Award Icahn School of Medicine at Mount Sinai received a $253,500 Project Grant award dated August 21, 2025, from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research project, titled "Longitudinal Single Cell Responses in Human Islet Organoids to Beta Cell Regenerative Drugs," will be conducted through June 30, 2027, and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Icahn School of Medicine at Mount Sinai $816,825 on April 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate how injured podocytes communicate with parietal epithelial cells to drive proliferative glomerulopathy, specifically whether podocyte-derived exosomes mediate this cell-to-cell signaling in rapidly progressive glomerulonephritis. The research uses...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Icahn School of Medicine at Mount Sinai $742,478 on July 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to elucidate how RNA-lipid nanoparticle transfection and expression in professional antigen-presenting cells and non-professional antigen-presenting cells—specifically hepatocytes and skeletal myocytes—modulate T cell responses to RNA-encoded protein. The...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Icahn School of Medicine at Mount Sinai $726,142 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of microbiota-specific T cells in inflammatory bowel disease. The research uses deep single-cell RNA and T cell receptor sequencing technologies to longitudinally profile T cell repertoire and phenotype in two parallel studies: human...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Icahn School of Medicine at Mount Sinai $889,856 on August 17, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate mechanisms by which metabolic-associated fatty liver disease (MASH) drives chronic kidney disease pathogenesis. The recipient will conduct three specific research aims over the performance period through April 30, 2031. Aim 1 confirms the...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Icahn School of Medicine at Mount Sinai $874,673 on August 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate how suppression of 5-aminolevulinic acid synthase 1 (ALAS1) enhances therapeutic RNA interference activity. The project tests a novel genetic strategy to improve the efficacy of small interfering RNAs (siRNAs) in extrahepatic tissues where...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Icahn School of Medicine at Mount Sinai $240,228 on April 3, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic research on immune-adipocyte crosstalk in regulating adipose thermogenesis. The recipient will investigate how immune cells and adipocytes interact within adipose tissue to control thermogenic function, with particular focus on the interleukin-10...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $910,670 to Icahn School of Medicine at Mount Sinai on August 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to characterize a cluster of single-nucleotide polymorphisms (SNPs) in the LILRB3 gene associated with post-transplant renal failure in kidney transplant recipients. The research characterizes four consecutive SNPs in LILRB3 that encode missense mutations...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Albert Einstein College of Medicine $636,766 on August 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to characterize the HLA class I immunopeptidome of primary human pancreatic islets in health and type 1 diabetes. The award funds three research aims. Aim 1 characterizes the constitutive HLA class I immunopeptidome of primary human islets with emphasis on type 1...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Icahn School of Medicine at Mount Sinai $571,200 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic research on mechanisms protecting pancreatic beta cells from dysfunction and death in diabetes. The award funds research into a novel small molecule compound (Compound 43) that acts as a molecular glue to stabilize the interaction between the carbohydrate response element binding protein (CHREBPA) and 14-3-3 proteins. The research aims to prevent CHREBPA's nuclear translocation, thereby suppressing the stress-inducible CHREBPB isoform that drives beta-cell dedifferentiation and death under metabolic or inflammatory stress. Preliminary studies show Compound 43 protects human beta cells from dedifferentiation, maintains glucose-stimulated insulin secretion, and improves glycemic control in diabetic mouse models. The funded research will define the molecular mechanisms by which Compound 43 protects human beta cells and develop the therapeutic potential of this approach across type 1 and type 2 diabetes. Performance occurs at Mount Sinai's location in New York, New York. The period of performance extends from August 1, 2026, through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $571.2k | 7/29/26 |