Project Grant R01DK149129

The National Institute of Diabetes and Digestive and Kidney Diseases awarded $910,670 to Icahn School of Medicine at Mount Sinai on August 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to characterize a cluster of single-nucleotide polymorphisms (SNPs) in the LILRB3 gene associated with post-transplant renal failure in kidney transplant recipients.

The research characterizes four consecutive SNPs in LILRB3 that encode missense mutations between two ITIM motifs binding SHP-1 and SHP-2 phosphatases. The funded work includes validation across transplant cohorts, analysis of pretransplant peripheral blood gene expression patterns in B and T cell activation, IL-17 signaling, ferroptosis regulation, and in vitro and mouse model studies of variant allele immune response and ferroptosis-associated cell death in macrophages. The grant supports investigation of whether these genetic factors contribute to inferior graft survival independent of HLA mismatches, socioeconomic factors, or comorbidities, and examination of associations between these SNPs and severity or complications of immune-related diseases in electronic health record-linked biobanks.

Performance occurs in New York, New York, with a period of performance through May 31, 2031. This is a Project Grant, the primary assistance type for NIH extramural research supporting basic and clinical biomedical research that improves understanding of disease mechanisms and leads to improved prevention, diagnosis, and treatment.