Project Grant R01DK148774
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Albert Einstein College of Medicine $887,696 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to profile plasma proteome across 2,300 individuals from the Hispanic Community Health Study/Study of Latinos (SOL) cohort, including repeated proteome measures in 1,000 individuals over approximately six years, using Olink Explore HT technology to measure...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Albert Einstein College of Medicine $252,000 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the metabolic function of a novel dual-modal hepatocyte subset. The funded research examines periportal hepatocytes that simultaneously express both gluconeogenic and lipogenic genes in the fed state, suggesting natural resistance to insulin...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Albert Einstein College of Medicine $183,558 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to implement and evaluate T1D-PATCHY, a community health worker–led specialty care model designed to increase diabetes device adoption among underserved youth with type 1 diabetes. The project addresses multi-level barriers to device use—including social needs and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded a $802,595 cooperative agreement to Pacific Northwest National Laboratory, a division of Battelle Memorial Institute, on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will conduct spatial multi-omics profiling of human pancreatic islet microenvironments to discover pathways and molecular mediators of early Type 1 Diabetes pathogenesis. The...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Albert Einstein College of Medicine $109,652 on September 16, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate chaperone-mediated autophagy failure in metabolic dysfunction-associated steatotic liver disease progression. The research examines how chaperone-mediated autophagy, a selective cellular degradation process, contributes to hepatic metabolic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Beckman Research Institute of the City of Hope $307,108 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic research on alpha cell heterogeneity in Type 1 Diabetes. The funded research will investigate functional heterogeneity within pancreatic alpha cell subpopulations and their regulatory interactions with neighboring beta and delta cells...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Icahn School of Medicine at Mount Sinai $571,200 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic research on mechanisms protecting pancreatic beta cells from dysfunction and death in diabetes. The award funds research into a novel small molecule compound (Compound 43) that acts as a molecular glue to stabilize the interaction between the...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $178,000 to Beckman Research Institute of The City of Hope on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate how the native pancreatic microenvironment regulates human islet cell function in health and type 1 diabetes. The research employs human pancreatic tissue slices to preserve native cellular architecture and directly compares hormone...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $178,000 to Beckman Research Institute of the City of Hope on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct three-dimensional spatial and translational profiling of stress response pathways in Type 1 Diabetes. The research examines how proinflammatory cytokines activate the integrated stress response in pancreatic beta cells during early Type 1...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Icahn School of Medicine at Mount Sinai $168,000 on May 7, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct research targeting ChREBPβ for beta-cell protection in Type 1 diabetes. The research characterizes the contribution of ChREBPβ (carbohydrate-responsive element-binding protein B), a stress-inducible transcription factor, to beta-cell dysfunction in...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Albert Einstein College of Medicine $636,766 on August 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to characterize the HLA class I immunopeptidome of primary human pancreatic islets in health and type 1 diabetes. The award funds three research aims. Aim 1 characterizes the constitutive HLA class I immunopeptidome of primary human islets with emphasis on type 1 diabetes susceptibility allotypes HLA-B39:06 and HLA-A24:02, providing a foundation for T cell epitope selection and understanding how the immunopeptidome changes with disease. Aim 2 explores the inflammatory islet immunopeptidome using islets from donors with type 1 diabetes, comparing it to the constitutive immunopeptidome of healthy donor islets cultured with and without inflammatory cytokines. Aim 3 evaluates candidate T cell epitopes identified from the islet immunopeptidome for recognition by blood and islet-derived CD8+ T cells from patients with type 1 diabetes. The work addresses the limited knowledge of beta cell antigen-derived peptides presented by HLA class I molecules and their role in triggering CD8 T cell responses that contribute to beta cell loss. Work is performed in Bronx, New York. The period of performance runs through June 30, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $636.8k | 8/27/26 |