Project Grant R01DK144042
- This $824,655 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research aimed at understanding the role of sex-biased transcription factors in conferring protection against metabolic dysfunction-associated steatotic liver disease (MASLD) in females. The research will use adult-onset, hepatocyte-specific knockdown technology to elucidate...
- The University of Southern California (USC) was awarded a $445,870 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, which runs from Sep 2, 2025 to Sep 1, 2027, will be used to develop a spatially patterned, mature, and functional human kidney organoid model by leveraging the plasticity of kidney progenitor cells. The goal is to overcome...
- This federal Project Grant award of $2,651,504.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to identify the mechanisms by which impaired long-chain fatty acid oxidation, due to liver-specific deletion of the CPT1A enzyme, leads to sexually dimorphic responses of microvesicular steatosis and reductions in circulating polyunsaturated...
- The University of Southern California (USC) was awarded a $807,860 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, titled "STROKE VOLUME-BASED FLUID RESUSCITATION IN AP (SUSTAIN)", aims to address the critical knowledge gap in optimal fluid therapy administration for acute pancreatitis (AP) treatment. The project will compare an...
- This federal Project Grant award of $239,213 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research to investigate the interplay between glucocorticoid signaling and histone acetyltransferase (HAT) regulation in erythropoiesis. The research aims to determine if glucocorticoid receptor directly interacts or colocalizes with HATs, and if HAT inhibition phenocopies...
- This $1,558,188 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate how changes in transcription factor and heterochromatin states in embryos and adult livers impact hepatocyte development, homeostasis, and regeneration. The project, led by researchers at the University of Pennsylvania, will utilize advanced...
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) will fund a $773,341 research project at the University of Southern California (USC) from Sep 1, 2025 to Aug 31, 2029. The project aims to identify the mechanisms linking food insecurity, diet quality, and liver disease progression in people with HIV. Specifically, the research will (1) examine the association of persistent...
- This Project Grant award of $200,664 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research at the University of California, San Francisco (UCSF) to investigate the immunological mechanisms and biomarkers underlying the development of autoimmune diabetes induced by immune checkpoint inhibitor cancer treatments. The key objectives are to: Analyze genetic predisposition to...
- This federal Project Grant award, with a total funding amount of $645,617, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is aimed at understanding the dysfunction of hematopoietic stem cells in refractory Crohn's disease, a condition that is resistant to traditional treatments. The research will profile hematopoietic stem cell populations...
- This federal Project Grant award of $122,454, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research investigating the role of the GIMAP5 gene in maintaining liver homeostasis. The primary recipient, Yale University, is conducting studies to determine how loss of function in the GIMAP5 gene leads to capillarization and dedifferentiation of liver...
The federal Project Grant award of $759,135 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research on the "Impact of Sex and Cell Death on Checkpoint Inhibitor Hepatotoxicity". The University of Southern California (USC) is the awardee and will conduct the research to investigate the mechanisms underlying immune-related liver injury resulting from immune checkpoint inhibitor cancer treatments, with a focus on understanding the role of sex differences. The project aims to aid in developing targeted treatments as alternatives to systemic steroids for this serious side effect. The award period is from September 8, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $759.1k | 9/5/25 |