Project Grant K08AI193076
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $287,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of California, San Francisco (UCSF). This 2-year project, running from April 2025 to March 2027, aims to determine if genetic mutations that alter IL-17 signaling contribute to the development of autoimmune diabetes. The grant supports UCSF's research to investigate how perturbations to...
- This $120,255 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate the impact of antigen-specific immunotherapy on the differentiation and function of effector T cells in autoimmune diabetic islet transplants. The study aims to determine how inducing tolerance to a hybrid insulin peptide can expand antigen-specific regulatory T cells that suppress autoreactive CD4 and CD8 T...
- This $380,000 federal Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), on August 1, 2025. The purpose of the grant is to develop a bifunctional RNA therapeutic called PS03 to modulate PD-L1 expression on B cells in order to induce exhaustion of diabetogenic T cells and prevent the onset of type 1 diabetes. Preliminary data suggests that systemic administration of PS03 can...
- This Project Grant award of $634,984 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of a specific B cell subset, termed BND2, in the autoimmune disorder type 1 diabetes (T1D). The research aims to: 1) elucidate the mechanism by which these insulin-reactive BND2 cells become activated and break anergy, 2) determine their fate and function as antigen-presenting...
- The Project Grant award of $429,000 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program supports research to investigate the role of pH in the pathogenesis of Type 1 Diabetes (T1D). The research, conducted by the University of Colorado-Denver, focuses on understanding how changes in acidity levels within insulin-producing cells can lead to the formation of hybrid insulin peptides (HIPs), which may be...
- This $858,186 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports a research project titled "Decoding T Cell Clonotypes, Biology and Predictive Biomarkers Associated with Immune Checkpoint Myocarditis." The project aims to investigate the mechanisms underlying immune-related myocarditis, a potentially fatal adverse event associated with immune checkpoint inhibitor cancer therapies. Using...
- This $441,202 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) is funding research to study the role of effector regulatory T cells (ExTregs) in autoimmunity and cancer immunity. The project aims to utilize genetic tracing models to monitor ExTregs and assess their contribution to immune responses when regulatory T cells (Tregs) are depleted. The research seeks to provide...
- This federal Project Grant award of $801,662, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research by the Scripps Research Institute to investigate the early phase of type 1 diabetes. The key objectives are to characterize the antigen-presenting cells associated with pancreatic islets during the pre-diabetic stage in mice, using advanced techniques...
- The federal Project Grant award of $759,135 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research on the "Impact of Sex and Cell Death on Checkpoint Inhibitor Hepatotoxicity". The University of Southern California (USC) is the awardee and will conduct the research to investigate the mechanisms underlying immune-related liver injury resulting...
- This $2,263,983 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to develop "engineered regulatory T cells (Tregs)" as an immunotherapy for type 1 diabetes. The central goal is to create antigen-specific Tregs that can more effectively suppress the autoimmune destruction of insulin-producing beta cells. The research...
This Project Grant award of $200,664 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research at the University of California, San Francisco (UCSF) to investigate the immunological mechanisms and biomarkers underlying the development of autoimmune diabetes induced by immune checkpoint inhibitor cancer treatments. The key objectives are to: This multifaceted research aims to enhance the mechanistic understanding of CPI-DM, with the goal of identifying potential targets for prevention or treatment of type 1 diabetes, both in the context of cancer immunotherapy and conventional disease. The project period runs from September 2025 through August 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $200.7k | 9/11/25 |