Project Grant R01DK144021
- This $3,255,832 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will support research at the University of Chicago to investigate the role of macrophages in weight loss-induced metabolic health and adipose tissue inflammation resolution. The project aims to determine the phenotype, function, and transcriptome of visceral and subcutaneous adipose tissue macrophages across mouse and human models, as well as test strategies like cell...
- This $2,060,811 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the role of activin type II receptor signaling in muscle hypertrophy, obesity, and weight loss. The research aims to understand how blocking the activin type II receptor can preserve lean muscle mass while maximizing fat loss during obesity treatment,...
- The University of Pennsylvania was awarded a $1,418,750 Project Grant from the National Institutes of Health (NIH) Trans-NIH Research Support Program (CFDA 93.310) to conduct research on "Optogenetic Engineering of Thermogenic Adipose Tissue as a Novel Cell Therapy for Obesity." The goal of this project is to develop new treatments to increase energy expenditure and combat the public health challenge of obesity, which affects over 40% of the U.S. population. The research aims to...
- This federal Project Grant award of $121,875 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the developmental origins and cellular composition of dermal adipose tissue, which plays a significant role in whole-body metabolism. The research aims to elucidate how a specific transcription factor, BCL11B, modulates the...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a component of the National Institutes of Health, awarded a $789,350 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Pennsylvania State University (Penn State) to investigate biological mechanisms of obesity in a high-risk pediatric cohort with confirmed maltreatment. The project aims to elucidate the impact of child maltreatment on obesity through...
- This $108,486 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to identify novel immune markers associated with obesity-driven diseases. The objective is to utilize novel tools to study the inter-organ communication pathway between the intestine and adipose tissue immune cells. The research leverages a Cre-inducible...
- This federal Project Grant award of $803,748 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is funding research to investigate the modulation of insulin signaling in adipocytes (fat cells) and how improved adipocyte insulin sensitivity can contribute to positive metabolic outcomes. The research team at The University of Texas Southwestern Medical...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $773,112 Project Grant to Rockefeller University on September 5, 2025 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the mechanisms of transcriptional control in adipocyte formation and function through nuclear receptor coactivators. The research aims to provide a better understanding of dysregulation in energy storage...
- This federal Project Grant award of $246,750.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), with a project period from August 15, 2025 to August 14, 2027. The award supports research by The Trustees of Columbia University in the City of New York to investigate how obesity affects the function of macrophages and T cells in the pancreas, and their role...
- This federal Project Grant award of $464,985, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on extracellular vesicles released by adipocytes (fat cells) and their potential role in cardiometabolic disease. The research, conducted by The Washington University, aims to investigate how these adipocyte-derived extracellular vesicles, including...
This $2,559,138 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to define the mechanisms regulating adipose (fat) tissue metabolic memory and its role in rebound weight gain following obesity treatment. The project, led by researchers at the University of Pennsylvania, aims to: 1) determine the role of LYVE1+ macrophages in directing the lineage allocation of maladaptive fat progenitor cells in obesity and weight loss, and 2) characterize the changes in extracellular matrix properties in obesity and weight loss that may impair adipose tissue regenerative capacity. The research leverages single-cell sequencing, 3D collagen hydrogel models, and other advanced techniques to understand the persistent cellular and extracellular changes in adipose tissue that contribute to the challenge of sustained weight loss. This 4-year award commenced on September 7, 2025 and is expected to run through August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.6m | 9/6/25 |