Project Grant R01DK143245
- Federal Grant Award Summary Boston University received a $168,252 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 15, 2025 through July 31, 2030. This five-year career development and research project investigates the molecular mechanisms of Nuclear Receptor Corepressor 1 (NCOR1) and Nuclear Receptor Corepressor 2 (SMRT) in...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $2.64 million project grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 1, 2025, through August 31, 2029. This research award funds an investigator-initiated project examining novel mitochondrial mechanisms in obesity pathogenesis, specifically...
- Federal Project Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $813,511 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective July 21, 2025, with a completion date of April 30, 2029. The research project, titled "Structural Basis of Thermogenic Mitochondrial Respiratory Complexes Assembly," focuses on understanding...
- Federal Project Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $840,198 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective July 21, 2025, with completion targeted for April 30, 2029. The award funds basic biomedical research aimed at understanding cellular and biochemical pathways of adipose metabolism and thermogenesis,...
- Federal Project Grant Award Summary Boston University Medical Campus received a $478,011 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 11, 2025, through August 31, 2027. The award funds development of an automated deep learning platform designed to analyze transmission electron microscopy (TEM) images of kidney tissue for...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $3.1 million Project Grant to Boston Children's Hospital under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for a four-year research initiative spanning September 3, 2025, through September 2, 2029. The research will investigate the role of lipogenic pathways in intestinal remodeling following Roux-en-Y gastric bypass (RYGB) surgery,...
- Federal Grant Award Summary Boston University Medical Campus received a $166,752 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 1, 2025, with completion targeted for May 31, 2030. This five-year career development training program supports Dr. Kaserman's research into the mechanisms of metabolic dysregulation in ZZ alpha-1 antitrypsin...
- Summary of Federal Project Grant Award The University of Texas Southwestern Medical Center received a $148,575 project grant from the National Institute of Diabetes and Digestive and Kidney Diseases under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 15, 2025, with completion targeted for July 31, 2030. The award supports basic biomedical research investigating the role of fibroblast growth factor 1 (FGF1) signaling in adipocytes...
- Federal Project Grant Award Summary The University of Pennsylvania received a $2,559,138 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 7, 2025, through August 31, 2029. The award funds research aimed at defining the mechanisms regulating adipose tissue metabolic memory and its role in rebound weight gain following weight loss...
- Federal Project Grant Award Summary The University of Pittsburgh received a $1,325,413 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective February 25, 2025, with completion anticipated by January 31, 2029. This research project investigates novel aspects of Growth Differentiation Factor 15 (GDF15) biology to advance understanding of...
Boston University Medical Campus received a $817,498 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective February 18, 2026, through January 31, 2031. The award funds basic biomedical research investigating vasculature remodeling and beige adipocyte recruitment in obese adipose tissue. The research will examine molecular pathways—specifically Serum Response Factor (SRF) and Myocardin-Related Transcription Factor A (MRTFA)—to develop strategies that inhibit pathological adipose tissue remodeling while enhancing the conversion of progenitor cells into thermogenic beige adipocytes as a potential obesity treatment. The research deliverables will advance understanding of how angiogenesis and progenitor cell fate decisions influence healthy adipose tissue expansion and metabolic homeostasis in obesity. By identifying mechanisms to promote beige adipocyte recruitment while preventing chronic inflammation and fibrosis, this investigation will generate foundational knowledge applicable to developing therapeutic interventions for obesity-related metabolic dysfunction and insulin resistance. The project will be conducted at Boston University Medical Campus in Roxbury, Massachusetts.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $817.5k | 2/18/26 |