Project Grant K08DK140640
- This federal Project Grant award of $544,963, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the protein frataxin (FXN) in metabolic dysfunction-associated steatotic liver disease (MASLD). The research conducted under this award will examine whether FXN deficiency induces and whether restoration of FXN expression prevents...
- This $1,558,188 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate how changes in transcription factor and heterochromatin states in embryos and adult livers impact hepatocyte development, homeostasis, and regeneration. The project, led by researchers at the University of Pennsylvania, will utilize advanced...
- This federal Project Grant award in the amount of $1,428,186.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Massachusetts. The project aims to investigate the role of CYP4F enzymes in regulating N-acyl amino acid signaling in humans, which has implications for understanding the early...
- This Project Grant award, valued at $172,060, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research conducted by The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to understand the mechanism of unfolded protein response (UPR) loss in human non-alcoholic steatohepatitis (NASH) and how the UPR...
- This Project Grant award, valued at $801,000.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at The Children's Hospital Corporation, doing business as Boston Children's Hospital, to investigate the role of stress granules in red blood cell development, particularly during stress conditions. The research aims to uncover the...
- This federal Project Grant award of $159,408, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research), supports research at The Children's Hospital of Philadelphia (CHOP) to elucidate the role of effector CD8 T-cell and Kupffer cell interferon-gamma interaction in pediatric activated T-cell acute liver failure. The 5-year project aims to help the principal investigator become an independent...
- This $128,286 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research into the mechanisms of renal lipotoxicity and its contribution to the development of chronic kidney disease (CKD). The principal investigator will investigate the protective role of the FAF2 gene knockout in mitigating palmitate-induced lipotoxicity in...
- This federal Project Grant award for $603,632, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, aims to define the role of the PLA2G12B protein in regulating the assembly, plasma levels, metabolism, and cardiovascular disease risk of apolipoprotein B (apoB)-containing lipoproteins. The primary grantee, The Johns Hopkins University, will leverage novel tools to investigate how...
- This $786,216 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on post-transcriptional regulation of hepatokines and their impact on systemic metabolism. The University of California, Los Angeles is conducting this research to investigate a novel mechanism by which the liver uses RNA-binding proteins to control the...
- This federal Project Grant award of $2,651,504.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to identify the mechanisms by which impaired long-chain fatty acid oxidation, due to liver-specific deletion of the CPT1A enzyme, leads to sexually dimorphic responses of microvesicular steatosis and reductions in circulating polyunsaturated...
This $166,752 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports a 5-year career development training program at Boston University Medical Campus focused on studying the basic mechanistic underpinnings of alpha-1 antitrypsin deficiency (AATD) associated liver disease. The goal is to develop new treatments for these patients while simultaneously providing the necessary training for the principal investigator, Dr. Kaserman, to become a future independent investigator. The research will utilize patient-derived induced pluripotent stem cell-hepatocytes to investigate how branch-specific activation of the unfolded protein response signaling pathways, particularly ATF6, preserves metabolic function and reduces steatosis in ZZ AATD hepatocyte subsets. The award commenced on September 1, 2025 and is scheduled for completion on May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $166.8k | 8/29/25 |