Federal Grant Award Summary

The University of Michigan received a $780,220 Project Grant award dated February 27, 2026, from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports a clinical optimization trial to evaluate the effectiveness of two scalable digital behavioral intervention components for mitigating Level 2 hypoglycemia (severe low blood glucose) in adults with Type 1 Diabetes (T1D) who continue to experience hypoglycemic episodes despite using advanced diabetes technologies such as continuous glucose monitoring and closed-loop insulin pumps. The research is scheduled for completion by January 31, 2030.

The project will deliver two automated, real-time digital intervention components delivered via Short Message Service (SMS) text messages: Digital Hypoglycemia Symptom Detection Training and Digital Hypoglycemia Psychoeducation. These interventions, guided by patient glucose data, aim to address the approximately one in three adults with diabetes who develop Level 2 hypoglycemia despite standard-of-care advanced technologies. The study will recruit 208 participants across the United States to determine the individual and combined effectiveness of each intervention component, ultimately selecting the optimized program that best balances clinical effectiveness with patient burden for future implementation and broader scalability.