Project Grant K23DK140535
- This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a systems biology research project conducted by the Regents of the University of Michigan. The key objectives are to: 1) Validate predicted transcription factor binding motifs related to the hypoxia-inducible factor 1-alpha (HIF1A) in areas of open chromatin using multiomics data, and 2)...
- This federal Project Grant award of $737,949 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to modernize clinical methods for assessing fluid excess and removal during in-center hemodialysis treatment. The long-term goal is to improve patient-centered outcomes by leveraging newer techniques like multi-frequency bioelectrical impedance spectroscopy...
- This Project Grant award, in the amount of $126,846, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports a translational research project to investigate the role of the gut microbiome in the pathogenesis of sepsis-associated acute kidney injury (AKI). The research, to be conducted at the University of Michigan, aims to identify gut bacteria...
- This $2,833,514 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, titled "Renal Metabolism in AKI", will fund research to investigate changes in kidney metabolism in sepsis-associated acute kidney injury (AKI) and their impact on kidney tubule injury and recovery. The University of California, San Diego (UCSD) is the awardee...
- This $199,990 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at The Ohio State University to investigate the role of the transcriptional corepressor CTBP2 as a metabolic sensor in acute kidney injury (AKI). The key objectives are to: 1) examine how acetylation regulates the nuclear localization and activation...
- This $155,562 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate the effect of activating branched chain amino acid (BCAA) catabolism in treating acute kidney injury (AKI) and the transition to fibrosis. The award recipient, The Research Foundation for The State University of New York (Stony Brook University), will conduct research to...
- This federal Project Grant award of $3,010,432 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding research to develop mitoprotective therapies for the treatment of acute kidney injury (AKI). The key objectives of this research are to characterize a novel mitochondrial protein target, phospholipid scramblase 3 (PLSCR3), and evaluate pharmacological activators...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is providing $173,664 to The Regents of the University of California, San Francisco (UCSF) to conduct research on "Molecular Characterization of Ascites Fluid to Identify Drivers of Infection in Patients with Decompensated Cirrhosis." The project aims to apply metagenomic...
- This $128,286 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research into the mechanisms of renal lipotoxicity and its contribution to the development of chronic kidney disease (CKD). The principal investigator will investigate the protective role of the FAF2 gene knockout in mitigating palmitate-induced lipotoxicity in...
- This federal Project Grant award, totaling $813,284.00 and provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports a research study on the relationship between acute kidney injury (AKI) and delirium in patients who have undergone cardiac surgery. The key objectives of this 5-year study are to: 1) determine the incidence and clinical characteristics of AKI-associated delirium in cardiac surgery patients, 2) delineate the signaling...
This $196,418 federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847), supports research aimed at utilizing biosignals and biomarkers to improve the safety and efficacy of albumin infusion in patients with cirrhosis and acute kidney injury (AKI). The key goals of the project are to: 1) predict the benefits and harms of albumin infusion for AKI using clinical data, 2) define a pulse oximeter waveform 'biosignature' associated with circulatory volume changes after albumin infusion, and 3) create a predictive model using clinical data and biosignals to determine albumin benefit in patients with cirrhosis. The award was made to the Regents of the University of Michigan, a prominent research university, to conduct this investigation over the period of September 1, 2025 to May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $196.4k | 7/22/25 |