Federal Grant Award Summary

The University of Michigan received a $878,614 Project Grant award effective March 1, 2026, through December 31, 2030, from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports implementation of precision medicine for glomerular diseases within the Nephrotic Syndrome Study Network (NEPTUNE), leveraging a mature research infrastructure established over 14 years that includes comprehensive clinical, histological, genetic, and molecular characterization of over 850 pediatric and adult patients with proteinuric glomerular diseases.

Under this award, the University of Michigan will develop and deploy two predictive treatment response models utilizing the NEPTUNE Knowledge Network. The first model will predict individual patient response to current Kidney Disease Improving Global Outcomes (KDIGO) recommended standard-of-care treatments for glomerular diseases to guide optimal therapy selection. The second model will predict, through the NEPTUNE MATCH Study framework, whether a patient's disease molecular pathways align with specific clinical trial interventions, providing trial recommendations to study participants and site investigators. These deliverables advance precision medicine application in glomerular disease treatment by matching the right intervention to the right patient at the right time, directly supporting the NIDDK's mission to improve prevention, diagnosis, and treatment outcomes for kidney diseases.