This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $695,295 to support research on developmental trajectories of reinforcer pathology and childhood obesity. The award, with a start date of March 15, 2025 and an ultimate completion date of January 31, 2030, will be executed by The Research Foundation For The State University Of...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the CFDA program "Diabetes, Digestive, and Kidney Diseases Extramural Research" (93.847), will provide $340,175 to American University to conduct research on the effects of federal funding for obesity prevention programs on weight-related health behaviors, obesity prevalence, and obesity-related chronic conditions. The project aims to leverage variation in county and...
This Project Grant award, totaling $1,825,466.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The University of Georgia Research Foundation, Inc. is the primary awardee conducting research to examine the impact of adolescent consumption of a Western diet high in saturated fat and added sugars on the development of impulsive eating behaviors. The...
The federal Project Grant award R21HD115119, totaling $531,174, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to develop and test novel dual agonist therapies targeting the melanocortin and gut-peptide receptors for the treatment of childhood obesity. The research plan includes two specific aims: 1) fully characterizing and optimizing a GLP-1R/MC4R dual...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $107,250 to the University of Oklahoma Health Sciences Center Division to conduct research on the role of NR2F2 in beige adipogenesis and its potential to mitigate childhood obesity risk. The award will fund investigations into how early-life exposure to omega-6 fatty acids impacts adipose stem cell fate and beige...
This $624,000 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) aims to investigate the impact of obesity and adiposity on the human endometrium. The research team at the Regents of the University of Michigan will use single-nuclear RNA sequencing, liquid chromatography mass-spectrometry, and functional endometrial assays to comprehensively assess how pathologic adiposity influences...
This Project Grant award, valued at $400,000 and awarded on September 5, 2024, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research conducted by the University of Mississippi Medical Center to investigate the role of insulin resistance in the development of renal disease during prepubertal childhood obesity, in the absence of diabetes....
This Project Grant award, valued at $498,065.02, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research conducted by the University of Pittsburgh to better understand the foundations of variation in adiposity and body composition in infancy and early life, with a focus on the CREBRF genetic variant and its effects in Pacific Islander populations. The...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $176,500.00 to the University of Washington to investigate the links between hypothalamic microglia activation and perineuronal net (PNN) loss in the arcuate nucleus, and how these changes contribute to the pathogenesis of diet-induced obesity and glucose regulation. The...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $660,773 over a 5-year period starting June 1, 2025 to assess the impact of obesity on the endometrium and the reversibility of these changes with weight loss after bariatric surgery. The research will use advanced proteomic, single-cell transcriptomic, and functional assays to characterize the...
This Project Grant award, totaling $799,756.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The purpose of the grant is to conduct a randomized controlled trial (RCT) to determine if a weight loss and positive health behavior change intervention in pre-pubertal girls at risk for earlier pubertal onset can slow their pubertal development. The University of Washington is the primary awardee and will lead the 5-year study starting on July 1, 2025. The research aims to address the significant health risks associated with earlier pubertal onset in disadvantaged girls, including depression, substance abuse, and long-term metabolic disorders. Key outcomes to be measured include pubertal hormone levels, pubertal staging, weight change, health behaviors, and metabolic factors. Findings from this study could inform new directions for existing obesity treatment programs and help disrupt the link between early obesity, accelerated puberty, and negative post-pubertal outcomes in vulnerable populations.