The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $840,198 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Dana-Farber Cancer Institute, Inc. (Dfci) in Boston, MA. The goal of this 4-year project is to better understand the mechanisms of energy expenditure and adipose thermogenesis in mammalian systems, with a focus on the futile creatine cycle pathway. Key objectives include determining how...
This Project Grant award of $604,853 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will fund research at Rockefeller University to elucidate the genetic determinants of human brown adipose tissue (BAT) function. The goal is to develop a better understanding of how BAT, which can protect against obesity and associated metabolic diseases, is regulated in humans. The research will leverage...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research, provides $1,152,102 to the University of California, Berkeley to study a potential new enhancer for the UCP1 gene, which is critical for activating thermogenesis in brown adipose tissue. The research aims to elucidate the role of this enhancer and an associated transcription factor in regulating UCP1...
This federal Project Grant award of $152,454 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the mechanistic role of the protein irisin in modulating immune response and adipose tissue dynamics. The primary awardee, Dana-Farber Cancer Institute, Inc., will conduct a multi-year study to: (1) elucidate the molecular pathways through which irisin...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $570,268 to the Albert Einstein College of Medicine to conduct research on the regulation of adipose tissue remodeling by the CCNC-Mediator. The research aims to study the cell-autonomous mechanisms and metabolic functions of enhanced white adipose tissue browning, as well as the cellular...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $1,329,941 to The Regents of the University of California, Berkeley (UC Berkeley) to conduct research on the role of biomechanical interfaces created by focal adhesion kinase in catecholamine signaling. The research aims to elucidate how biomechanical forces regulate beta-adrenergic receptor signaling in beige...
This Project Grant award of $854,803 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program will fund the creation of a comprehensive and user-friendly curated data repository for indirect calorimetry experiments related to body weight regulation. The repository will enable researchers to easily share, access, and reanalyze data on the effects of altered behaviors and various disease...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,600,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Icahn School of Medicine at Mount Sinai. The project, titled "Decoding Endocrine and Paracrine Communication Through Mammokines," aims to discover new signaling molecules from the mammary gland that influence metabolic function and the progression of obesity and type 2...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $245,123 to support research on the role of vascular sympathetic neurons in brown adipose tissue and their impact on systemic metabolism. The project, led by The Trustees of Columbia University in the City of New York, aims to use novel genetic and chemogenetic tools, advanced...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,428,186.00 to Beth Israel Deaconess Medical Center, Inc. (BIDMC) to conduct research on the role of CYP4F enzymes in regulating N-acyl amino acid signaling in humans. The project aims to biochemically characterize N-acyl amino acids as substrates and inhibitors of CYP4F...