This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $551,112 to Children's Hospital Los Angeles (CHLA) to elucidate the role of deep crypt secretory (DCS) cells in colonic inflammation and tissue repair. The project aims to 1) determine if impaired DCS cell responses exacerbate colonic inflammation and limit tissue regeneration, 2)...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $339,000.00 to New York University (NYU) School of Medicine to conduct research on the genetic factors underlying Hirschsprung disease, a rare developmental disorder. The research aims to comprehensively characterize the genetic basis of Hirschsprung disease by analyzing whole genome sequencing data...
This Project Grant award, ID R01DK137771, is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program. The $1,882,623 award will support research at the Cincinnati Children's Hospital Medical Center to investigate the epigenetic regulation of intestinal tuft cells and how microbial metabolites influence their development and function. The research aims to uncover novel...
This Project Grant award, totaling $233,600.00 and spanning September 1, 2024 to June 30, 2027, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports high-throughput functional analyses of genetic drivers of inflammatory bowel disease (IBD), a debilitating condition characterized by chronic inflammation and erosion of intestinal functions. The...
This $2,175,283 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to reprogram intestinal immunity in preterm neonates to prevent and cure necrotizing enterocolitis (NEC), a severe and often fatal intestinal disease. The award funds a collaborative effort led by the University of North Carolina at Chapel Hill to utilize a large NEC biorepository,...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) for $516,648 supports research to investigate whether intestinal stem cells (ISCs) maintain an "inflammatory memory" following exposure to helminth infection, and how this impacts their regenerative capacity. The funded project, led by investigators at the University of California, San Francisco (UCSF), aims to...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $151,643 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Colorado-Denver. The grant supports research to develop proteolysis targeting chimeras (PROTACs) that can stabilize hypoxia-inducible factors (HIF) to enhance barrier formation and wound healing in inflammatory bowel disease models. The project aims to elucidate the...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $708,138 to Ann & Robert H Lurie Children's Hospital of Chicago to develop a small molecule-releasing scaffold for bladder augmentation. The goal is to promote anatomically correct and physiologically functional bladder tissue regeneration, as an alternative to traditional enterocystoplasty surgical approaches...
This Project Grant award, totaling $216,736.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research project aims to identify the mechanisms by which the host circadian clock and gut microbiome regulate mucus production in the large intestine to protect against infectious and chemical colitis. Key objectives include determining the specific microbiota...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research to elucidate the genotype-phenotype relationships and underlying mechanisms of celiac disease (CED) and inflammatory bowel diseases (IBD). The $580,274 award, with a performance period from August 19, 2024, to July 31, 2029, will fund a collaborative multi-PI effort between researchers at Hackensack University Medical Center (HMH...