Project Grant R01DK141598
- This federal Project Grant award of $242,100.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will support research by Mayo Clinic to investigate the role of sphingolipid metabolism in regulating regulatory T cell function and intestinal homeostasis, with the goal of developing new therapeutic strategies for inflammatory bowel disease. The project...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,255,725 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Icahn School of Medicine at Mount Sinai. The funding will support the development of a solid-state fermentation platform for manufacturing defined live biotherapeutic products (LBPs) comprised of in vitro manufactured bacterial strains. This represents a scalable approach to...
- This federal Project Grant award of $228,948 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Weill Medical College of Cornell University to investigate the role of the neuropeptide adrenomedullin 2 (ADM2) in regulating intestinal inflammation and promoting tissue protection in inflammatory bowel diseases (IBD) such as ulcerative...
- This Project Grant award of $234,000 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the University of Colorado-Denver to investigate the role of the Aiolos transcriptional regulator in the pathogenesis of inflammatory bowel disease. The researchers aim to utilize CRISPR-Cas9 genome editing to examine how Aiolos regulates T cell...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $758,542 to Cedars-Sinai Medical Center to conduct research on the role of the Pyrin Domain-Only Protein 3 (POP3) in regulating type I interferon and ameliorating intestinal inflammation. The goal is to determine the protective impact of POP3 on intestinal homeostasis and...
- This federal Project Grant award, with a total funding amount of $645,617, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is aimed at understanding the dysfunction of hematopoietic stem cells in refractory Crohn's disease, a condition that is resistant to traditional treatments. The research will profile hematopoietic stem cell populations...
- This $859,704 Project Grant was awarded on July 2, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research by Weill Medical College of Cornell University to investigate the role of the protein AGR2 in regulating host-microbe interactions and inflammatory processes in Crohn's disease. The research aims to enhance understanding of the cellular...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $132,677 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on mapping genetic variants associated with inflammatory bowel disease (IBD) to their target genes and functional effects in human macrophages. The project aims to elucidate the transcriptional consequences of IBD candidate genes in monocytes and...
- This $303,427 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847, Diabetes, Digestive, and Kidney Diseases Extramural Research, supports the development of secretory IgA (sIgA) derived from human milk as a therapeutic for inflammatory bowel disease (IBD). The project aims to rigorously test the efficacy of this human milk-derived sIgA product for oral delivery to protect against the inflammation and dysregulation characteristic...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $3,233,421 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Yale University. The grant, with a performance period of September 1, 2025 to August 31, 2029, will support research to investigate the role of neutrophils in the pathogenesis of cholangiopathies - chronic liver diseases affecting bile ducts. The research aims to elucidate the...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $680,687 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Cedars-Sinai Medical Center in California. The 5-year grant, awarded on August 15, 2025, supports research to investigate anti-Malassezia lipase antibodies (AMLAB) as a novel biomarker for identifying subsets of patients with inflammatory bowel disease (IBD). The research aims to characterize the clinical and genetic features of IBD patients with elevated AMLAB, assess the impact of AMLAB on innate immune responses to Malassezia, and evaluate the relationship between AMLAB and anti-Malassezia T cell responses in the gut mucosa. The goal is to shed light on the underlying mechanisms driving IBD development and persistence, with the potential to inform the tailoring of treatment approaches for these patient populations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $680.7k | 8/14/25 |