Project Grant R41DK143877
- This federal Project Grant award of $790,359, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to develop a targeted probiotic yeast therapeutic for treating inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. The research project aims to design, characterize, and optimize a fibronectin-targeting, nanobody...
- This federal Project Grant award of $112,026 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to The Washington University in St. Louis, Missouri. The award will support research to characterize the interactions between secretory IgA (sIgA) and the gut microbiome, particularly Akkermansia muciniphila, and how these relationships are impacted by autoimmunity...
- This Project Grant award of $234,000 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the University of Colorado-Denver to investigate the role of the Aiolos transcriptional regulator in the pathogenesis of inflammatory bowel disease. The researchers aim to utilize CRISPR-Cas9 genome editing to examine how Aiolos regulates T cell...
- This federal Project Grant award of $242,100.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will support research by Mayo Clinic to investigate the role of sphingolipid metabolism in regulating regulatory T cell function and intestinal homeostasis, with the goal of developing new therapeutic strategies for inflammatory bowel disease. The project...
- The Salk Institute for Biological Studies received a $562,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the functions of specialized intestinal T cells, called intraepithelial lymphocytes (IELs), that are recruited to the mammary gland during lactogenesis. The central hypothesis is that these entero-mammary IELs promote maternal-offspring immunity by regulating...
- This federal Project Grant award of $458,047.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to understand how extracellular vesicles (EVs) from intestinal epithelial cells (enterocytes) mediate cell-to-cell communication and function as effectors of inflammation in inflammatory bowel disease (IBD). Specific objectives include identifying...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate gut microbial functions that impact Crohn's disease risk. Specifically, the $235,500 award to Rutgers, The State University of New Jersey will generate shotgun metagenomic sequencing data from samples collected from multiplex Crohn's disease families....
- This federal Project Grant award of $3,340,009 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate the potential causal role of periodontitis (a prevalent oral infection) in inflammatory bowel disease (IBD). The University of Maryland, Baltimore is the primary awardee and will leverage animal models to determine if oral bacteria from IBD patients and...
- This federal Project Grant award of $228,948 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Weill Medical College of Cornell University to investigate the role of the neuropeptide adrenomedullin 2 (ADM2) in regulating intestinal inflammation and promoting tissue protection in inflammatory bowel diseases (IBD) such as ulcerative...
- This $172,232 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to understand the causes of inflammatory bowel disease (IBD) therapy failure. The principal investigator, Dr. Simon M. Gray, a gastroenterologist at the University of North Carolina at Chapel Hill, will leverage a pre-clinical mouse model to study the immunologic and...
This $303,427 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847, Diabetes, Digestive, and Kidney Diseases Extramural Research, supports the development of secretory IgA (sIgA) derived from human milk as a therapeutic for inflammatory bowel disease (IBD). The project aims to rigorously test the efficacy of this human milk-derived sIgA product for oral delivery to protect against the inflammation and dysregulation characteristic of IBD, which affects nearly 1% of the U.S. population. The funding will support in vitro and in vivo humanized model studies to evaluate the protective role of this sIgA product on mucosal barrier and immune function. The award period is from September 1, 2025 to August 31, 2026, and the work is being conducted by Lactiga US Inc. in North Brunswick Township, New Jersey.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/17/25 | ||
| Not listed | $303.4k | 8/29/25 |