Project Grant R01DK141150

Award Date 7/15/24
Completion Date 6/30/28
Dollars Obligated $603K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
New York, NY 10032, USA
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This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), focuses on investigating the role of lymph node stromal cells in maintaining peripheral tolerance and reducing autoimmunity in type 1 diabetes. The primary awardee, The Trustees of Columbia University in the City of New York, will receive $602,531 to conduct research aimed at:

  1. Evaluating the impact of modifying the ability of lymph node fibroblastic reticular cells (FRCs) to express and present type 1 diabetes-relevant antigens on autoimmunity development in mouse models.

  2. Testing the capability of human lymph node-derived FRCs to modulate HLA-matched human T cell responses and reduce cytotoxicity on primary and stem cell-derived pancreatic beta cells in vitro.

The project will also involve sub-awards to the University of Miami and University Health Network to leverage their expertise in immunoengineering, lymph node stromal cell biology, and stem cell-derived pancreatic beta cell technologies. The goal is to advance the understanding of how lymph node stromal cells can contribute to peripheral tolerance and inform potential therapeutic applications for type 1 diabetes.

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