Project Grant R01DK141106

Award Date 8/20/24
Completion Date 6/30/29
Dollars Obligated $731K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
New York, USA
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This federal Project Grant award of $726,140.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to elucidate the neural circuits and cellular mechanisms underlying visceral pain processing in the spinal cord and brainstem, with the goal of advancing understanding and treatment of visceral pain conditions such as irritable bowel syndrome,...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate the role of urothelial cells in bladder sensory function and pain signaling. The $521,019 award to The Medical College of Wisconsin, Inc. aims to functionally and molecularly identify the sensory neuron populations that respond to urothelial cell...
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This Project Grant award, with the ID R01DK141106, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $730,883 grant will fund research by the Icahn School of Medicine at Mount Sinai (ISMMS) to investigate the molecular and cellular mechanisms underlying visceral pain and cross-organ sensitization between the bladder and colon. The key objectives are to: 1) use chemogenetic and viral-mediated approaches to determine the role of MRGPRB2+ mast cell-TRPV1+ nociceptor clusters in bladder pain and bladder-colon cross-sensitization; and 2) identify the mechanisms by which bladder inflammation induces colon pain, including the potential contribution of the mast cell-derived LTC4-neuronal CYSLTR2 axis. This 5-year project, awarded on August 20, 2024, aims to provide critical insights into the cellular and molecular basis of visceral pain conditions, which could lead to new therapeutic approaches for treating these disorders.

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