This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports the development of selective degradation strategies to target mutant transcription factors. The $253,500.00 award will fund experiments to design and test approaches to selectively degrade the mutant variant of the KLF1 transcription factor, which is implicated in...
This Project Grant award of $949,056, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research by Northwestern University to investigate the functional roles of the DDX41 gene in the homeostasis of G-quadruplexes during erythropoiesis. The research aims to elucidate the molecular and cellular mechanisms by which DDX41 mutations contribute to the...
This Project Grant award of $1,560,024 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 supports research on the intracellular trafficking and signaling of the metabolite heme in myeloid cells. The primary awardee, Scripps Research Institute, will leverage mouse models, chemical tools, and new mouse mutants to reveal a molecular pathway for how heme signaling regulates the differentiation and function of macrophages under normal and disease...
This Project Grant award, with Federal Grant ID R01DK140461, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $740,000 award to St. Jude Children's Research Hospital Inc. will support research to investigate the role of the extracellular matrix (ECM) in the specification of hematopoietic stem cells (HSCs) during vertebrate embryonic development. The key...
This $1,540,684 Project Grant, awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the heterogeneous responses of bone marrow across the skeletal system under stress conditions. The primary awardee, Childrens Hospital Medical Center, will investigate how bone marrow macrophages and competition between erythroid progenitors and...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $143,968.00 to support research on early detection and treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA). The research aims to examine whether markers of endothelial injury and complement overactivation can predict HSCT-TMA, as well...
This Project Grant award of $493,310.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research on the role of the SHP2 protein in regulating the bone marrow stroma and its impact on hematopoiesis. The study aims to investigate how SHP2 depletion affects the osteogenic, adipogenic, and stromogenic differentiation of osterix-positive stromal progenitor...
This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a systems biology research project conducted by the Regents of the University of Michigan. The key objectives are to: 1) Validate predicted transcription factor binding motifs related to the hypoxia-inducible factor 1-alpha (HIF1A) in areas of open chromatin using multiomics data, and 2)...
This federal Project Grant award of $248,915.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research aimed at "Unravelling the Role of Epigenetics and Cytokines in Type 2 Diabetes among African-Ancestry Populations." The key objectives are to infer causal relationships between lifestyle factors, genetic regulatory...
This $249,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to elucidate the molecular mechanisms controlling hematopoietic stem cell (HSC) fate choices, including symmetric self-renewal, symmetric commitment, and asymmetric divisions. The research aims to characterize the HSC-like intermediate state controlled by m6A RNA...