This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $773,257 to St. Jude Children's Research Hospital Inc. to investigate the mechanisms of lysosome segregation and cell fate regulation in dividing hematopoietic stem cells (HSCs). The research aims to identify factors regulating lysosome segregation during HSC division and how this process influences HSC self-renewal and...
This Project Grant award of $734,607 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to elucidate the key endothelial mechanisms that direct hematopoietic stem cells (HSCs) across the blood vessel wall and into their niche. The research, conducted by Boston Medical Center Corporation, will use high-resolution live cell imaging, structure-function studies, and in vivo proximity-dependent biotinylation in zebrafish to define the endothelial...
The National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) awarded a $915,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Florida (UF) on September 10, 2024. The goal of this 5-year research project is to expand the understanding of hematopoietic stem and progenitor cell (HSPC) fate and function following major trauma, including examining interventions to reduce stress/inflammation and restore the microbiome...
This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research, supports research to understand how mutations in the SRCAP gene promote the development of therapy-related clonal hematopoiesis and therapy-related myeloid neoplasms. The $465,155 award to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Incorporated, will fund...
This $682,472 federal Project Grant award from the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program supports research by the Sanford Burnham Prebys Medical Discovery Institute (SBP) to selectively target mutant SHP2 oncoproteins in rare leukemias. The award will fund SBP's efforts to advance understanding of the fundamental mechanisms of disease and develop innovative therapies, with a focus on areas such as cancer, aging, neurodegenerative...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $1,123,357 in funding to the Children's Hospital Medical Center in Cincinnati, Ohio for a research program focused on understanding the bone marrow microenvironment and its role in regulating blood cell production. The key goals of the 7-year research program are to: 1) Dissect the function of specialized microenvironments that serve as niches for different blood...
This $428,973 Project Grant was awarded on September 20, 2024 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate the functional divergence of two critical ribosomal proteins, RPL27 and RPS19, in the model organism Schizosaccharomyces pombe. The study aims to clarify whether differences in cellular phenotypes resulting from the absence of these ribosomal protein...
This $677,600 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to gain a mechanistic understanding of erythroid progenitor (EP) self-renewal, both in vitro and in vivo. The primary goals are to: Test the hypothesis that the BMI1/RING1B chromatin modulators regulate human self-renewing erythroblast (SRE) self-renewal through epigenetic control of transcription and cholesterol homeostasis. Test the hypothesis that...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $421,600.00 to The Morgridge Institute for Research, Inc. to conduct research focused on understanding the interplay of genetic and environmental contributions to human cell fitness. The key products and services to be delivered through this 5-year award include: 1) Investigating context-dependent genetic contributions...
This $249,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to elucidate the molecular mechanisms controlling hematopoietic stem cell (HSC) fate choices, including symmetric self-renewal, symmetric commitment, and asymmetric divisions. The research aims to characterize the HSC-like intermediate state controlled by m6A RNA...