This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,399,467 to The Johns Hopkins University to investigate the cellular and molecular mechanisms by which integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) leads to weight gain, particularly in women. The research aims to: 1) define the molecular pathways by...
This $780,853 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research at the University of Pittsburgh examining the impact of a glucagon-like peptide-1 receptor agonist on SIV/HIV pathogenesis and antiretroviral therapy (ART) in people living with HIV. Key objectives include assessing changes to T-cell and macrophage metabolism, immune...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $840,198 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Dana-Farber Cancer Institute, Inc. (Dfci) in Boston, MA. The goal of this 4-year project is to better understand the mechanisms of energy expenditure and adipose thermogenesis in mammalian systems, with a focus on the futile creatine cycle pathway. Key objectives include determining how...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $570,268 to the Albert Einstein College of Medicine to conduct research on the regulation of adipose tissue remodeling by the CCNC-Mediator. The research aims to study the cell-autonomous mechanisms and metabolic functions of enhanced white adipose tissue browning, as well as the cellular...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to determine the developmental origins and regulation of dermal adipose tissue. The $121,875 award, granted on April 5, 2025, will be performed by the University of Pennsylvania and aims to: (1) elucidate the mechanisms by which the transcription factor BCL11B...
This Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to determine the structural basis of thermogenic mitochondrial respiratory complexes and their role in adipocyte function, obesity, and type 2 diabetes. The $813,511 award to Dana-Farber Cancer Institute, Inc. will fund a 4-year research project to: 1) Characterize the...
This Project Grant award of $777,336.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research aims to define the molecular mechanism of gut inflammation and barrier dysfunction in people with HIV (PWH). The overarching goal is to understand how HIV infection and antiretroviral therapy (ART) impact gut barrier integrity, with a focus on the role of the CARD8 inflammasome. The research will...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $2,024,509 to Baylor College of Medicine to investigate the role of microRNA-30a (miR-30a) in regulating the immune response of white adipose tissue (WAT) and its impact on insulin sensitivity in obesity. The 5-year project aims to define the effects of cell-specific miR-30a expression,...
This federal Project Grant award of $152,454 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the mechanistic role of the protein irisin in modulating immune response and adipose tissue dynamics. The primary awardee, Dana-Farber Cancer Institute, Inc., will conduct a multi-year study to: (1) elucidate the molecular pathways through which irisin...
This Project Grant award of $604,853 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will fund research at Rockefeller University to elucidate the genetic determinants of human brown adipose tissue (BAT) function. The goal is to develop a better understanding of how BAT, which can protect against obesity and associated metabolic diseases, is regulated in humans. The research will leverage...