This federal Project Grant award, valued at $520,649, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at the Albert Einstein College of Medicine to dissect the development and functional differences between hematopoietic stem cells (HSCs) and HSC-independent progenitor cells during embryonic development. The project aims to uncover...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $1,393,740 to The Children's Hospital Corporation (Boston Children's Hospital) to conduct research on the endothelial cell niche for hematopoietic stem cells. The research aims to functionally characterize the interaction between endothelial cells and hematopoietic stem cells, with the goal of developing new...
This $249,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to elucidate the molecular mechanisms controlling hematopoietic stem cell (HSC) fate choices, including symmetric self-renewal, symmetric commitment, and asymmetric divisions. The research aims to characterize the HSC-like intermediate state controlled by m6A RNA...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $773,257 to St. Jude Children's Research Hospital Inc. to investigate the mechanisms of lysosome segregation and cell fate regulation in dividing hematopoietic stem cells (HSCs). The research aims to identify factors regulating lysosome segregation during HSC division and how this process influences HSC self-renewal and...
This Project Grant award of $734,607 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to elucidate the key endothelial mechanisms that direct hematopoietic stem cells (HSCs) across the blood vessel wall and into their niche. The research, conducted by Boston Medical Center Corporation, will use high-resolution live cell imaging, structure-function studies, and in vivo proximity-dependent biotinylation in zebrafish to define the endothelial...
This $475,020 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of the N-terminus of the GATA1 transcription factor in regulating erythropoiesis. The project aims to: 1) identify the cofactors recruited by the N-terminus to regulate erythropoiesis, and 2) explore the N-terminus' role in controlling...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $295,438 to the University of Florida to develop a novel ex vivo expansion platform for human hematopoietic stem cells (HSCs). The goal is to significantly increase the availability of suitable HSC donors for hematopoietic stem cell transplantation and improve post-transplant recovery, which is critical for treating life-threatening blood and bone marrow...
This Project Grant award of $497,806.97 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to elucidate molecular programs that can be targeted to enhance umbilical cord blood hematopoietic stem cell (HSC) function and engraftment for improved hematopoietic cell transplantation (HCT) outcomes. The research plan involves examining combinations of treatments such as DPP4 inhibition and physioxic isolation of HSCs to determine their...
This $225,306 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project between researchers at the University of Southern California (USC) and a German partner to investigate the long-term impact of early-life growth signals on adult hematopoietic (blood) stem cell function and selection. The key products and services to be delivered under this 3-year award include: 1) using stem cell transplantation and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program provides $508,750.00 to St. Jude Children's Research Hospital Inc. over a period from June 5, 2025 to March 31, 2030. The funding supports research to uncover the epigenetic mechanisms that underlie stem cell fate decisions during embryogenesis. The project focuses on understanding how histone H3 lysine 27 (H3K27) modifiers, such as...