Project Grant R01DK139679
Award Date
9/10/24
Completion Date
8/31/28
Dollars Obligated
$704K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19104, USA
Similar Awards
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $168,886.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research titled "Elucidating the Role of NAD+ and PARylation in Nephron Endowment." The award aims to study how maternal availability of nicotinamide adenine dinucleotide...
This federal Project Grant award of $293,128 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research will support research by The Johns Hopkins University to uncover the role of the G-protein coupled receptor GPR39 in kidney physiology. The research aims to examine the mechanisms by which GPR39 activation influences water reabsorption in the kidney and determine the physiologic function of...
This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a systems biology research project conducted by the Regents of the University of Michigan. The key objectives are to: 1) Validate predicted transcription factor binding motifs related to the hypoxia-inducible factor 1-alpha (HIF1A) in areas of open chromatin using multiomics data, and 2)...
This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to define the role of iron homeostasis in the responses of proximal tubular epithelial cells to kidney fibrosis, which is a key driver of chronic kidney disease (CKD) progression. The $199,922 award to Weill Medical College of Cornell University will support experiments to...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
This Project Grant award of $1,188,167 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847, the Diabetes, Digestive, and Kidney Diseases Extramural Research program, supports research to develop inhibitors of the sphingosine 1-phosphate (S1P) signaling pathway as potential therapies for chronic kidney disease (CKD). The primary awardee, Virginia Polytechnic Institute & State University (Virginia Tech), will work to improve the oral...
This $400,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the earliest events in podocyte injury in collagen IV nephropathies. The goal is to investigate how processing of mutant collagen IV proteins injures podocytes at early stages, leading to chronic kidney disease and renal failure. The research uses...
This Project Grant award of $400,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to explore the role of insulin resistance in the development of renal disease during prepubertal childhood obesity. The research aims to investigate how insulin resistance alters glucose transport and energy metabolism in renal proximal tubules, potentially leading to...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research focused on understanding the molecular and genetic mechanisms underlying ischemic acute kidney injury (AKI). The $117,000 award, with a performance period from August 2024 to July 2026, will investigate the hypothesis that the transcription factor PAX8 controls sensitivity to...
The federal Project Grant award, totaling $1,504,974, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to establish that at least a subset of minimal change disease (MCD) and primary focal and segmental glomerulosclerosis (FSGS) are mediated by an organ-specific, antibody-driven autoimmune disease that causes acquired podocyte injury. Key...