This federal Project Grant award of $152,454 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the mechanistic role of the protein irisin in modulating immune response and adipose tissue dynamics. The primary awardee, Dana-Farber Cancer Institute, Inc., will conduct a multi-year study to: (1) elucidate the molecular pathways through which irisin...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Duke University a $241,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to study the regulation of metabolic diseases by the human commensal bacterium Clostridium immunis. The overarching goal is to determine the mechanism by which an exopolysaccharide (EPS) secreted by C. immunis decreases visceral adiposity, a key risk factor for type 2 diabetes and...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $570,268 to the Albert Einstein College of Medicine to conduct research on the regulation of adipose tissue remodeling by the CCNC-Mediator. The research aims to study the cell-autonomous mechanisms and metabolic functions of enhanced white adipose tissue browning, as well as the cellular...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate the role of microRNA146a (miR146a) in regulating autoimmunity in type 1 diabetes (T1D). The $107,948 award, effective from Apr 21, 2025 to May 31, 2027, will enable Case Western Reserve University to use novel miR146a-knockout NOD mice, T1D patient samples, and...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,475,096 to assess the interrelationship between adipose tissue thermogenesis and fibrosis in the metabolic health of people living with HIV (PLWH). The project aims to examine how reduced capacity of CD81+ adipogenic precursor cells to maintain normal subcutaneous adipose tissue...
This Project Grant award of $847,746 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the role of the UPR transducer XBP1 in pancreatic beta cell survival and function under metabolic stress. The research aims to elucidate the impact of XBP1S overexpression on beta cell integrity and the potential mechanisms underlying dynamic beta cell...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $176,500.00 to the University of Washington to investigate the links between hypothalamic microglia activation and perineuronal net (PNN) loss in the arcuate nucleus, and how these changes contribute to the pathogenesis of diet-induced obesity and glucose regulation. The...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,600,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Icahn School of Medicine at Mount Sinai. The project, titled "Decoding Endocrine and Paracrine Communication Through Mammokines," aims to discover new signaling molecules from the mammary gland that influence metabolic function and the progression of obesity and type 2...
This $626,429 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research to investigate the role of the carbohydrate responsive element binding protein (CHREBP) and its isoforms in liver metabolism and metabolic disorders. The project aims to resolve contradictory findings on CHREBP's effects and better understand its influence on conditions like metabolic-associated steatohepatitis, dyslipidemia, and cardiometabolic diseases....
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $840,198 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Dana-Farber Cancer Institute, Inc. (Dfci) in Boston, MA. The goal of this 4-year project is to better understand the mechanisms of energy expenditure and adipose thermogenesis in mammalian systems, with a focus on the futile creatine cycle pathway. Key objectives include determining how...