Project Grant R01DK139114
Award Date
8/27/24
Completion Date
7/31/29
Dollars Obligated
$898K
Similar Awards
This Project Grant award, totaling $1,244,042.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will support a collaborative project executed by three early-stage investigators to validate the relevance of mouse models in representing human benign prostatic hyperplasia (BPH). The project aims to develop new approaches for correlating...
This Project Grant award, valued at $629,250.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to examine the role of hyaluronic acid (HA) in the pathobiology of benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS). The primary objectives are to characterize the relationship between HA,...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $598,609 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, MA. The grant, running from September 20, 2024 to July 31, 2029, aims to clinically evaluate mechanisms of resistance to the 5α-reductase inhibitor finasteride, a common drug used to manage benign prostatic hyperplasia (BPH) and...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $511,084.00 to Beth Israel Deaconess Medical Center, Inc. (Bidmc) to study the mechanisms of non-responsiveness to steroid 5α-reductase inhibitors (5ARI) in the treatment of benign prostatic hyperplasia (BPH). The research aims to elucidate how the epigenetic silencing of the...
The National Institute on Aging (NIA) awarded a $489,509 Project Grant (CFDA 93.866 - Aging Research) to the Magee-Womens Research Institute And Foundation to conduct research on steroid hormone pathways regulating benign prostate hyperplasia (BPH) and lower urinary tract symptoms (LUTS) associated with aging. The 2-year project aims to: Identify proteins and pathways involved in promoting smooth muscle relaxation and bladder voiding that are dysregulated in aged mouse prostate models and...
This is a Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $632,600 grant will support research to understand the role of antimicrobial peptides called defensins in immunity against urinary tract infections (UTIs) caused by uropathogenic E. coli. The research aims to characterize how defensins synthesized by bladder epithelial cells contribute...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate the role of urothelial cells in bladder sensory function and pain signaling. The $521,019 award to The Medical College of Wisconsin, Inc. aims to functionally and molecularly identify the sensory neuron populations that respond to urothelial cell...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop and test optimized formulations of a combination drug therapy for the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The $318,488 award will fund feasibility studies in dogs and mice to identify the most desirable pharmacokinetic parameters and...
This federal Project Grant award of $830,500.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research), supports research to investigate the role of glycosphingolipids in the development and progression of kidney disease in obesity and diabetes. The award, effective January 20, 2025 through November 30, 2028, will fund studies conducted by Georgetown University to test hypotheses that...
This federal Project Grant award of $640,001.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award, which runs from January 1, 2025 to November 30, 2028, supports research conducted by Yale University to explore the mechanisms by which the protein polycystin-1 (PC1) and its C-terminal fragments affect mitochondrial function and cellular energy...