Project Grant R01HL171622

Award Date 8/1/24
Completion Date 7/31/28
Dollars Obligated $797K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Houston, TX 77030, USA
Similar Awards
This $762,867 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program supports research to investigate the role of the protein cofilin-1 in mitochondrial quality control mechanisms that impact airway epithelial dysfunction in chronic bronchitis, a subtype of chronic obstructive pulmonary disease (COPD). The project aims to determine how the loss of cofilin-1 affects mitochondrial dynamics, mitophagy, and...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $616,000.00 to Northwestern University to conduct research on the role of mitochondrial metabolism in alveolar epithelial cell fate. The study aims to determine whether an increased mitochondrial NADH/NAD+ ratio and activation of the integrated stress response (ISR) pathway preclude normal alveolar epithelial differentiation,...
This $730,494 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to determine the underlying mechanisms for dysregulation of glucose barrier function in cystic fibrosis-related diabetes (CFRD). The project aims to identify mechanisms linking mutant CFTR expression to altered insulin receptor function, glucose barrier function, and impacts of hyperglycemia and oxidative stress in...
The federal Project Grant award R01HL172490 for $693,306.00 was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports research to examine the role of fatty acid oxidation and the mitochondrial protein CPT1A in regulating alveolar epithelial cell differentiation and resilience against lung fibrosis. The research aims to determine how CPT1A-mediated fatty acid oxidation in alveolar type 2 (AT2) cells...
The federal Project Grant award R01HL171201, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of the METTL3 gene in the cardiac benefits of exercise for individuals with diabetes. The $599,921 award will fund a 5-year project to: 1) determine the role of METTL3 in the cardiac response to exercise in diabetes, 2) examine the effects of METTL3 in diabetic cardiomyopathy, and...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $684,814 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the suppression of alveolar stem cells by tissue-resident lymphocytes in emphysema. The research aims to investigate how lung stromal factors alter the inflammatory response to viral infections and tobacco smoke, and how this impacts...
This federal Project Grant award of $1,405,336.00 was made on September 1, 2024 by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports research at Florida International University (FIU) focused on understanding the pathophysiological mechanisms of HIV-associated chronic obstructive pulmonary disease (COPD). The key research objectives are to: 1) Identify how HIV Tat protein and cigarette smoke exposure alter the...
This $596,809.00 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to target the mitochondrial protein MitoNEET to address pulmonary hypertension (PH) secondary to lung disease (Group 3 PH). The research team at Emory University will conduct in vitro and in vivo studies to define how MitoNEET regulates pulmonary artery smooth muscle cell (PASMC) mitochondrial function and proliferation, as well...
This $3,443,108 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), supports research to investigate the role of mitochondrial calcium uptake in lung epithelial regeneration following bacterial pneumonia. The project aims to elucidate how calcium-dependent metabolic changes and histone lysine demethylation regulate the gene program required for alveolar epithelial type 2 (AT2) cell...
This federal Project Grant award of $915,924.00 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate how disruptions to the infant lung microbiome can impact the development and function of lung-resident immune cells and epithelial cells, leading to long-term pulmonary health issues. The key objectives are to: 1) examine how perinatal microbial dysbiosis affects the accrual and fate of...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), is funding a $796,760 research project titled "Protective Effects of Metformin Against Cigarette Smoke-Induced Lung Pathologies via Regulation of Fatty Acids Metabolism" under the Cardiovascular Diseases Research program (CFDA 93.837). The primary awardee, Baylor College of Medicine, will use the funding to investigate how the diabetes drug metformin can protect alveolar type 2 epithelial cells from cigarette smoke-induced dysfunction and improve mitochondrial function and fatty acid oxidation in these cells. The research aims to elucidate the mechanisms by which metformin can mitigate the development of emphysema and other chronic obstructive pulmonary disease (COPD) pathologies. The project involves a sub-award of $47,501 to Trinity College Dublin to provide expertise in measuring surfactant-related lipids and mitochondrial function in isolated mouse and human alveolar cells.

Generated 6/10/25, 2:56 AM