This Project Grant award, with a total funding amount of $519,068, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The purpose of the award is to define the molecular and systemic role of the intrinsic adipocyte (fat cell) molecular circadian clock and how it is impacted by obesity in humans. The research will establish whether human subcutaneous adipose...
This federal Project Grant award, with a total funding amount of $111,750, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to optimize a weight-neutral lifestyle intervention to improve health among adults with higher body weight. The project will leverage evidence-based interventions targeting mechanisms such as eating in response to...
This federal Project Grant award of $766,551 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is funding a multi-site collaboration to develop strategies for optimizing the use of anti-obesity medications (AOMs) to maximize their population health benefits. The key objectives are to: 1) understand the patient, provider, and system-level factors influencing AOM use; 2)...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $148,568 to support research investigating the physiological regulation of energy intake during meals following weight loss. The award will fund a study to analyze energy balance and gut hormone data from the ARROW Study (R01DK114272) and the TIME2EAT Study (R01DK132372) to better...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of activin type II receptor signaling in regulating muscle hypertrophy, obesity, and weight loss. The total funding amount is $2,060,811.00 for the project period from December 1, 2024 to November 30, 2029. The primary objectives are to explore how activin type II...
This $631,896 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to compare different remote-based behavioral weight loss interventions and identify factors that characterize treatment response. The award will fund a 2x2 factorial study to evaluate the effectiveness of an automated online program vs. a group-based videoconference program, as...
This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund a study to analyze the impact of federal funding for obesity prevention programs on weight-related health behaviors, obesity prevalence, and obesity-related chronic conditions. The $340,175 award, which runs from September 1, 2024 to June 30, 2029, will leverage variation in which...
This federal Project Grant award, with a total funding of $714,440, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award aims to advance precision diabetes medicine by: 1) defining metabolic subphenotypes in prediabetes and early type 2 diabetes, 2) evaluating heterogeneity in responses to diet, metformin, and liraglutide interventions according to...
This $143,874 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to identify mechanisms by which resistance exercise training (RET) enhances muscle insulin sensitivity. The award will support research at the Mayo Clinic to: 1) measure synthesis rates of individual muscle proteins in response to RET using stable isotope labeling in human...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Duke University a $241,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, titled "Regulation of Metabolic Diseases by Clostridium Immunis," will fund research to determine the mechanisms by which a novel human commensal bacterium, Clostridium Immunis, and its exopolysaccharide can reduce visceral adiposity and protect against...