Project Grant R01DK138465
Award Date
9/1/24
Completion Date
6/30/27
Dollars Obligated
$883K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
St. Louis, MO 63110, USA
Similar Awards
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $191,234 to Beth Israel Deaconess Medical Center, Inc. over the period of August 1, 2025 to July 31, 2030. The funding supports research to examine the role of gastric dopaminergic signaling and gastrointestinal mucosal injury in Parkinson's disease. Key objectives include investigating...
This federal Project Grant award of $227,205, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the effects of the Parkinson's disease-associated protein LRRK2 on lysosomal function and inflammatory activity in microglia. The research, conducted by Northwestern University, aims to: 1) examine how LRRK2 and the Parkinson's...
This $1,589,602 Cooperative Agreement awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support a multidisciplinary study to investigate the role of altered gut immune response in Lewy body diseases (LBD), which include Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The study aims to characterize peripheral involvement in PD and isolated REM sleep...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) totaling $1,007,304 supports research to investigate how genetic variants associated with inflammatory bowel diseases (IBD) affect the function of pathogenic T helper 17 (Th17) cells. The research aims to: Use massively parallel reporter assays (MPRAs) to identify putatively causal IBD variants within the accessible...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a 5-year research program focused on defining novel neuro-immune pathways that regulate gut physiology. The $168,296 award to Weill Medical College of Cornell University aims to investigate the role of enzymes in group 3 innate lymphoid cells (ILC3s) and their impact on inflammatory bowel disease (IBD) and...
The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,227,232 Cooperative Agreement (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Rush University Medical Center and partners to conduct a 5-year study on the gut-microbiota-brain axis in Parkinson's disease. The project will leverage existing and newly recruited patient cohorts to evaluate how disruptions in this biological axis contribute to Parkinson's disease severity...
This federal Project Grant award of $1,198,646.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to understand the role of lysosomes, a key cellular organelle, in regulating intestinal stem cells and their contribution to intestinal tumorigenesis. The research aims to characterize how the transcription factors TFE3 and TFEB orchestrate the lysosomal...
This Project Grant award of $467,200.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at Baylor College of Medicine to conduct high-throughput functional analyses of genetic drivers of inflammatory bowel disease (IBD). The research aims to 1) screen and characterize IBD risk genes in a C. elegans microbiome model, and 2) validate IBD risk alleles in human intestinal...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $1,000,100 Cooperative Agreement to The General Hospital Corporation (doing business as Massachusetts General Hospital) on September 1, 2024. The award will fund a consortium to study gut-brain communication in Parkinson's disease (PD). Key objectives include: Contributing PD patients and healthy controls to a...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) provides $1,739,177 to The Leland Stanford Junior University to conduct research on the role of impaired cellular RNA editing in the etiology of inflammatory bowel disease (IBD). The research aims to: Leverage genetic data to prioritize double-stranded RNA (dsRNA) loci associated with IBD susceptibility and systematically assess how risk and protective alleles affect dsRNA editing....